Immunocytochemistry (ICC)
(Immunocytochemistry: Representative lot data. Confocal fluorescent analysis of HeLa, A431, and NIH/3T3 using anti-FOXH1 antibody (Red). Actin filaments have been labeled with Alexa Fluor 488-Phalloidin (Green). Nuclei are stained with DAPI (Blue). Antibody shows positive nuclear staining.)
Rabbit anti-Human, Mouse FOXH1 Polyclonal Antibody | anti-FOXH1 antibody
FOXH1 (Forkhead Box H1, Human Homolog of Xenopus Forkhead Activin Signal Transducer 1) (MaxLight 750)
Applications are based on unconjugated antibody.
Immunocytochemistry (ICC)
(Immunocytochemistry: Representative lot data. Confocal fluorescent analysis of HeLa, A431, and NIH/3T3 using anti-FOXH1 antibody (Red). Actin filaments have been labeled with Alexa Fluor 488-Phalloidin (Green). Nuclei are stained with DAPI (Blue). Antibody shows positive nuclear staining.)
Immunocytochemistry (ICC)
(Immunocytochemistry: Representative lot data. Confocal fluorescent analysis of HeLa, A431, and NIH/3T3 using anti-FOXH1 antibody (Red). Actin filaments have been labeled with Alexa Fluor 488-Phalloidin (Green). Nuclei are stained with DAPI (Blue). Antibody shows positive nuclear staining.)
NCBI and Uniprot Product Information
NCBI Description
FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT. [provided by RefSeq, Jul 2008]
Uniprot Description
FOXH1: Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).
Protein type: Nuclear receptor co-regulator; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: nucleoplasm; transcription factor complex; nuclear chromatin; nucleus
Molecular Function: protein domain specific binding; protein binding; androgen receptor binding; DNA binding; sequence-specific DNA binding; bHLH transcription factor binding; SMAD binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; axial mesoderm development; embryonic heart tube anterior/posterior pattern formation; transforming growth factor beta receptor signaling pathway; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; heart looping; negative regulation of estrogen receptor signaling pathway
Disease: Holoprosencephaly 1
Research Articles on FOXH1
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Product Notes
The FOXH1 foxh1 (Catalog #AAA6477071) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FOXH1 (Forkhead Box H1, Human Homolog of Xenopus Forkhead Activin Signal Transducer 1) (MaxLight 750) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's FOXH1 can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC). ICC: 1:500 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the FOXH1 foxh1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FOXH1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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