Rabbit anti-Human FNTB Polyclonal Antibody | anti-fntb antibody

FNTB, NT (Protein Farnesyltransferase Subunit beta, FTase-beta, CAAX Farnesyltransferase Subunit beta, RAS Proteins Prenyltransferase Subunit beta)

Cat. Num. AAA630174

• Gene Names: fntb; fptb; FTase-beta
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: FNTB; Polyclonal Antibody; NT (Protein Farnesyltransferase Subunit beta; FTase-beta; CAAX Farnesyltransferase Subunit beta; RAS Proteins Prenyltransferase Subunit beta); Anti -FNTB; anti-fntb antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human FNTB.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.09% sodium azide.

• Applicable Applications for anti-fntb antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Western Blot, and Immunohistochemistry.; Dilution: ELISA: 1:1,000; Western Blot: 1:100-1:500; Immunohistochemistry: 1:50-1:100
• Immunogen: Synthetic peptide selected from the N-terminal region of human FNTB (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of FNTB (arrow) using FNTB Antibody (N-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FNTB gene (Lane 2) (Origene Technologies).)

Immunohistochemistry (IHC)

(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)

Related Product Information for anti-fntb antibody

Eukaryotic cells contain 3 different types of prenyltransferases that attach either a farnesyl group (15 carbons) or a geranylgeranyl group (20 carbons) in thioether linkage to C-terminal cysteine residues in a variety of proteins. These posttranslational modifications provide a mechanism for membrane localization of proteins that lack a transmembrane domain. CAAX farnesyltransferase (FTase) attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This enzyme has the ability to farnesylate peptides as short as 4 residues in length that conform to the CAAX consensus sequence. The gene for the beta subunit of CAAX farnesyltransferase (FNTB) has been pinpointed to 14q23-q24 by Southern blot hybridization and PCR analyses of panels of human/Chinese hamster somatic cell hybrid lines and by fluorescence chromosomal in situ hybridization.

Product Categories/Family for anti-fntb antibody

Antibodies; Abs to Enzymes;  Transferase

NCBI and Uniprot Product Information

• NCBI GI #: 62857869
• NCBI GeneID: 550012
• NCBI Accession #: NP_001017258.1
• NCBI GenBank Nucleotide #: NM_001017258.2
• NCBI Official Full Name: farnesyltransferase, CAAX box, beta
• NCBI Official Synonym Full Names: farnesyltransferase, CAAX box, beta
• NCBI Official Symbol: fntb
• NCBI Official Synonym Symbols: fptb; FTase-beta
• NCBI Protein Information: farnesyltransferase, CAAX box, beta