Rabbit FNBP1 Polyclonal Antibody | anti-FNBP1 antibody

FNBP1 Antibody

Cat. Num. AAA9631021

• Gene Names: FNBP1; FBP17
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: FNBP1; Polyclonal Antibody; FNBP1 Antibody; FBP1; FBP17; Fnbp1; FNBP1_HUMAN; Formin binding protein 1; Formin binding protein 17; Formin-binding protein 1; Formin-binding protein 17; hFBP17; KIAA0554; MGC126804; anti-FNBP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: FNBP1 Antibody detects endogenous levels of FNBP1.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-FNBP1 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human FNBP1.
• Conjugation: Unconjugated
• Similarity: The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation. Belongs to the FNBP1 family.
• Subunit Structure: Interacts specifically with GTP-bound RND2 and CDC42. Interacts with PDE6G and microtubules (By similarity). Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures. Interacts with AKAP9, ARHGAP17, DAAM1, DIAPH1, DIAPH2, DNM1, DNM2, DNM3, FASLG/FASL, SNX2 and WASL/N-WASP. May interact with TNKS.
• Tissue Specificity: Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain.
• Function: May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4, 5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.
• Note: Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-FNBP1 antibody

Cytoplasm; Cytoskeleton; Cell cortex; Lysosome; Cytoplasmic vesicle; Cell membrane; Peripheral membrane protein; Cytoplasmic side; Membrane; Clathrin-coated pit; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 38524622
• NCBI GeneID: 23048
• NCBI Accession #: NP_055848.1
• NCBI GenBank Nucleotide #: NM_015033.2
• UniProt Accession #: Q96RU3; O60301; Q3MIN8; Q5TC87; Q5TC88; Q6P658; Q7LGG2; Q9H8H8; Q9NWD1; B7ZL12; E9PGQ4
• Molecular Weight: 71,184 Da
• NCBI Official Full Name: formin-binding protein 1 isoform 1
• NCBI Official Synonym Full Names: formin binding protein 1
• NCBI Official Symbol: FNBP1
• NCBI Official Synonym Symbols: FBP17
• NCBI Protein Information: formin-binding protein 1
• UniProt Protein Name: Formin-binding protein 1
• Protein Family: Formin-binding protein
• UniProt Gene Name: FNBP1
• UniProt Synonym Gene Names: FBP17; KIAA0554; hFBP17

NCBI Description

The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human. [provided by RefSeq, Jul 2008]

Uniprot Description

May act as a link between RND2 signaling and regulation of the actin cytoskeleton (). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.