Rabbit anti-Human FLRT2 Polyclonal Antibody | anti-FLRT2 antibody

FLRT2 Antibody

Cat. Num. AAA9630626

• Reactivity: Human
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: FLRT2; Polyclonal Antibody; FLRT2 Antibody; Fibronectin leucine rich transmembrane protein 2; Fibronectin-like domain-containing leucine-rich transmembrane protein 2; KIAA0405; Leucine rich repeat transmembrane protein; Leucine rich repeat transmembrane protein FLRT2; anti-FLRT2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: FLRT2 Antibody detects endogenous levels of FLRT2.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-FLRT2 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human FLRT2.
• Conjugation: Unconjugated
• Post Translational Modifications: N-glycosylated.Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease.
• Subunit Structure: Self-associates (via leucine-rich repeats), giving rise to homooligomers. Interacts with FGFR1. Interacts with FGFR2. Interacts (via extracellular domain) with ADGRL1/LPHN1. Interacts (via extracellular domain) with ADGRL3 (via olfactomedin-like domain). Interacts (via extracellular domain) with UNC5D (via the first Ig-like domain). Can also interact (via extracellular domain) with UNC5B, but with much lower affinity. Interacts (via extracellular domain) with FN1.
• Tissue Specificity: Expressed in pancreas, skeletal muscle, brain, and heart.
• Function: Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis.
• Note: Proteolytic cleavage gives rise to a shedded ectodomain.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-FLRT2 antibody

Cell membrane; Single-pass membrane protein; Endoplasmic reticulum membrane; Cell junction; Focal adhesion; Secreted; Extracellular space; Extracellular matrix; Microsome membrane; Synapse; Synaptosome; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 7019381
• NCBI GeneID: 23768
• NCBI Accession #: NP_037363
• NCBI GenBank Nucleotide #: NM_013231.5
• UniProt Accession #: O43155; A0AV84; B7ZLP3
• Molecular Weight: 57.5kDa (514aa) 50-70KDa (SDS-PAGE under reducing conditions.)
• NCBI Official Full Name: leucine-rich repeat transmembrane protein FLRT2
• NCBI Official Synonym Full Names: fibronectin leucine rich transmembrane protein 2
• NCBI Official Symbol: FLRT2
• NCBI Protein Information: leucine-rich repeat transmembrane protein FLRT2
• UniProt Protein Name: Leucine-rich repeat transmembrane protein FLRT2
• Protein Family: Leucine-rich repeat transmembrane protein
• UniProt Gene Name: FLRT2
• UniProt Synonym Gene Names: KIAA0405

NCBI Description

This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Uniprot Description

Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis.