Western Blot/Blotting
(Western blot using antigen immunoaffinity purified and FLAP antibody on human kidney cell lysate. Lysate used at 15 ug/lane. Antibody used at 5 ug/ml. Secondary antibody, mouse anti-rabbit HRP , used at 1:75k dilution.)
Rabbit anti-Human FLAP Polyclonal Antibody | anti-FLAP antibody
FLAP
Western Blot/Blotting
(Western blot using antigen immunoaffinity purified and FLAP antibody on human kidney cell lysate. Lysate used at 15 ug/lane. Antibody used at 5 ug/ml. Secondary antibody, mouse anti-rabbit HRP , used at 1:75k dilution.)
Western Blot/Blotting
(Western blot using antigen immunoaffinity purified and FLAP antibody on human kidney cell lysate. Lysate used at 15 ug/lane. Antibody used at 5 ug/ml. Secondary antibody, mouse anti-rabbit HRP , used at 1:75k dilution.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
Uniprot Description
Function: Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. Ref.1 Ref.6
Subunit structure: Homotrimer. Interacts with LTC4S and ALOX5. Ref.10 Ref.12
Subcellular location: Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.6 Ref.7 Ref.10.
Domain: The C-terminal part after residue 140 is mostly unstructured. Ref.12
Involvement in disease: Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.8Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (Ref.8), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (Ref.9) ALOX5AP is not implicated in this condition.
Sequence similarities: Belongs to the MAPEG family.
Research Articles on FLAP
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Product Notes
The FLAP alox5ap (Catalog #AAA396064) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FLAP reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FLAP can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the FLAP alox5ap for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FLAP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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