Rabbit anti-Human, Mouse FKBP25 / FKBP3 Polyclonal Antibody | anti-FKBP25 antibody

Rabbit Polyclonal (IgG) to Human FKBP25 / FKBP3

Cat. Num. AAA243461

• Gene Names: FKBP3; FKBP-3; FKBP25; PPIase; FKBP-25
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: FKBP25 / FKBP3; Polyclonal Antibody; Rabbit Polyclonal (IgG) to Human FKBP25 / FKBP3; Anti-FKBP25 / FKBP3 Antibody IHC-plus; FKBP3; 25 kDa FK506-binding protein; 25 kDa FKBP; FKBP-3; Immunophilin FKBP25; FK506-binding protein 3; FK506-binding protein 3 (25kD); PPIase FKBP3; Rapamycin binding protein; Rotamase; PPIase; FK506 binding protein 3; 25kDa; FKBP-25; FKBP25; Human FKBP25; anti-FKBP25 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human FKBP25. Predicted cross-reactivity based on amino acid sequence homology: mouse (93%), rat (94%), bovine (97%).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: 0.1 M Tris-glycine, pH 7, 20% Glycerol, 0.01% Thimerosal
• Sequence Length: 224

• Applicable Applications for anti-FKBP25 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (5 ug/ml), WB (1:500 - 1:3000)
• Target Species: Human
• Immunogen Description: Recombinant protein fragment containing a sequence corresponding to a region within amino acids 2 and 195 of Human FKBP25.
• Immunogen Type: Recombinant protein
• Immunogen: FKBP25 / FKBP3 antibody was raised against recombinant protein fragment containing a sequence corresponding to a region within amino acids 2 and 195 of Human FKBP25.
• Preparation and Storage: Aliquot and store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-FKBP3 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Western Blot (WB)

(Sample (30 ug of whole cell lysate). A: A431. B: H1299. 12% SDS PAGE. FKBP3 antibody diluted at 1:1000.)

NCBI and Uniprot Product Information

• NCBI GI #: 4503727
• NCBI GeneID: 2287
• NCBI Accession #: NP_002004.1
• NCBI GenBank Nucleotide #: NM_002013.3
• UniProt Accession #: Q00688; Q14317; B2R4Q9
• Molecular Weight: 25,177 Da
• NCBI Official Full Name: peptidyl-prolyl cis-trans isomerase FKBP3
• NCBI Official Synonym Full Names: FK506 binding protein 3, 25kDa
• NCBI Official Symbol: FKBP3
• NCBI Official Synonym Symbols: FKBP-3; FKBP25; PPIase; FKBP-25
• NCBI Protein Information: peptidyl-prolyl cis-trans isomerase FKBP3; rotamase; 25 kDa FKBP; PPIase FKBP3; immunophilin FKBP25; rapamycin binding protein; 25 kDa FK506-binding protein; FK506-binding protein 3 (25kD); FK506-binding protein 25, T-cell; rapamycin-selective 25 kDa immunophilin
• UniProt Protein Name: Peptidyl-prolyl cis-trans isomerase FKBP3
• UniProt Gene Name: FKBP3
• UniProt Synonym Gene Names: FKBP25; PPIase FKBP3; 25 kDa FKBP; FKBP-25; FKBP-3
• UniProt Entry Name: FKBP3_HUMAN

NCBI Description

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]

Uniprot Description

FKBP3: FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. Belongs to the FKBP-type PPIase family.

Protein type: Isomerase; EC 5.2.1.8

Chromosomal Location of Human Ortholog: 14q21.2

Cellular Component: endoplasmic reticulum membrane; nucleus

Molecular Function: protein binding; FK506 binding; peptidyl-prolyl cis-trans isomerase activity; receptor activity

Biological Process: protein peptidyl-prolyl isomerization