Rabbit FHL3 Polyclonal Antibody | anti-FHL3 antibody

FHL3 Rabbit Polyclonal

Cat. Num. AAA769344

• Gene Names: FHL3; SLIM2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: FHL3; Polyclonal Antibody; FHL3 Rabbit Polyclonal; anti-FHL3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 280

• Applicable Applications for anti-FHL3 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Immunogen: Four and a half LIM domains 3
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human ovary tumor using MBS769344 (FHL3 antibody) at dilution of 1:50)

Western Blot (WB)

(K-562 cells were subjected to SDS PAGE followed by western blot with MBS769344 (FHL3 antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 54112385
• NCBI GeneID: 2275
• NCBI Accession #: NP_004459.2
• NCBI GenBank Nucleotide #: NM_004468.4
• Molecular Weight: 31,192 Da
• NCBI Official Full Name: four and a half LIM domains protein 3 isoform 1
• NCBI Official Synonym Full Names: four and a half LIM domains 3
• NCBI Official Symbol: FHL3
• NCBI Official Synonym Symbols: SLIM2
• NCBI Protein Information: four and a half LIM domains protein 3
• UniProt Protein Name: Four and a half LIM domains protein 3
• Protein Family: Four and a half LIM domains protein
• UniProt Gene Name: FHL3
• UniProt Synonym Gene Names: SLIM2; FHL-3; SLIM-2
• UniProt Entry Name: FHL3_HUMAN

NCBI Description

The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Uniprot Description

FHL3:

Protein type: Actin-binding; Contractile

Chromosomal Location of Human Ortholog: 1p34

Cellular Component: focal adhesion; nucleus; stress fiber; Z disc

Molecular Function: actin binding; protein binding; zinc ion binding

Biological Process: actin cytoskeleton organization and biogenesis; muscle development