Western Blot (WB)
(All lanes : Anti-FGF14 Antibody (C-term) at 1:2000 dilutionLane 1: SH-SY5Y whole cell lysatesLane 2: human brain lysatesLane 3: human cerebellum lysatesLane 4: mouse brain lysatesLane 5: rat brain lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilutionPredicted band size : 28 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Rabbit FGF14 Polyclonal Antibody | anti-FGF14 antibody
FGF14 Antibody (C-term)
Western Blot (WB)
(All lanes : Anti-FGF14 Antibody (C-term) at 1:2000 dilutionLane 1: SH-SY5Y whole cell lysatesLane 2: human brain lysatesLane 3: human cerebellum lysatesLane 4: mouse brain lysatesLane 5: rat brain lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilutionPredicted band size : 28 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Western Blot (WB)
(All lanes : Anti-FGF14 Antibody (C-term) at 1:2000 dilutionLane 1: SH-SY5Y whole cell lysatesLane 2: human brain lysatesLane 3: human cerebellum lysatesLane 4: mouse brain lysatesLane 5: rat brain lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilutionPredicted band size : 28 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Bonner T.I.,et al.Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
Chumakov I.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:13675-13680(2002).
Dunham A.,et al.Nature 428:522-528(2004).
van Swieten J.C.,et al.Am. J. Hum. Genet. 72:191-199(2003).
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
FGF14: Probably involved in nervous system development and function. Defects in FGF14 are the cause of spinocerebellar ataxia type 27 (SCA27). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA27 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder, with onset in late-childhood to early adulthood, characterized by ataxia with tremor, orofacial dyskinesia, psychiatric symptoms and cognitive deficits. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytokine; Cell development/differentiation
Chromosomal Location of Human Ortholog: 13q34
Cellular Component: extracellular region; nucleus
Molecular Function: heparin binding; growth factor activity; fibroblast growth factor receptor binding
Biological Process: nervous system development; synaptic transmission; fibroblast growth factor receptor signaling pathway; cell-cell signaling; adult locomotory behavior; neuromuscular process; JNK cascade; signal transduction
Disease: Spinocerebellar Ataxia 27
Research Articles on FGF14
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Product Notes
The FGF14 fgf14 (Catalog #AAA9213631) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FGF14 Antibody (C-term) reacts with Human, mouse, rat and may cross-react with other species as described in the data sheet. AAA Biotech's FGF14 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:2000. Researchers should empirically determine the suitability of the FGF14 fgf14 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FGF14, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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