FGF14 recombinant protein

Recombinant Human FGF14 protein, C-His Tag

Cat. Num. AAA157451

• Gene Names: FGF14; FHF4; FHF-4; SCA27; FGF-14
• Purity: >90% as determined by SDS-PAGE
• Synonyms: FGF14; Recombinant Human FGF14 protein; C-His Tag; FHF4; FGF14 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from 50 mM Tris-HCl pH 7.4, 150 mM NaCl, 0.02% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Source: Human
• Reconstitution: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
• Construction: A DNA sequence encoding the human FGF14 (Met1-Thr252?isoform2) was fused with the C-terminal His Tag
• Preparation and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for ~12 months from the date of receipt.; Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise

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Product Categories/Family for FGF14 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 4758368
• NCBI GeneID: 2259
• NCBI Accession #: NP_004106.1
• NCBI GenBank Nucleotide #: NM_004115.3
• UniProt Accession #: Q92915; Q86YN7; Q96QX6
• Molecular Weight: 28,462 Da
• NCBI Official Full Name: fibroblast growth factor 14 isoform 1A
• NCBI Official Synonym Full Names: fibroblast growth factor 14
• NCBI Official Symbol: FGF14
• NCBI Official Synonym Symbols: FHF4; FHF-4; SCA27; FGF-14
• NCBI Protein Information: fibroblast growth factor 14; bA397O8.2; fibroblast growth factor homologous factor 4
• UniProt Protein Name: Fibroblast growth factor 14
• Protein Family: Fibroblast growth factor
• UniProt Gene Name: FGF14
• UniProt Synonym Gene Names: FHF4; FGF-14; FHF-4
• UniProt Entry Name: FGF14_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

FGF14: Probably involved in nervous system development and function. Defects in FGF14 are the cause of spinocerebellar ataxia type 27 (SCA27). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA27 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder, with onset in late-childhood to early adulthood, characterized by ataxia with tremor, orofacial dyskinesia, psychiatric symptoms and cognitive deficits. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Cell development/differentiation

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: extracellular region; nucleus

Molecular Function: heparin binding; growth factor activity; fibroblast growth factor receptor binding

Biological Process: synaptic transmission; nervous system development; fibroblast growth factor receptor signaling pathway; cell-cell signaling; adult locomotory behavior; neuromuscular process; JNK cascade; signal transduction

Disease: Spinocerebellar Ataxia 27