Rabbit anti-Human FGD3 Polyclonal Antibody | anti-FGD3 antibody

FGD3, CT (FGD3, ZFYVE5, FYVE, RhoGEF and PH domain-containing protein 3, Zinc finger FYVE domain-containing protein 5)

Cat. Num. AAA6007742

• Gene Names: FGD3; ZFYVE5
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: FGD3; Polyclonal Antibody; CT (FGD3; ZFYVE5; FYVE; RhoGEF and PH domain-containing protein 3; Zinc finger FYVE domain-containing protein 5); Anti -FGD3; anti-FGD3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-FGD3 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: FGD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 574-601 amino acids from the C-terminal region of human FGD3.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(FGD3 Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the FGD3 antibody detected the FGD3 protein (arrow).)

Related Product Information for anti-FGD3 antibody

FGD3 promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho-and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity).

Product Categories/Family for anti-FGD3 antibody

Antibodies; Abs to Transcription Factors; Zinc (Ring) Finger

NCBI and Uniprot Product Information

• NCBI GI #: 31322344
• NCBI GeneID: 89846
• UniProt Accession #: Q5JSP0; Q4VX84; Q7Z7D9; Q8N5G1
• Molecular Weight: 79,401 Da
• NCBI Official Full Name: FGD3
• NCBI Official Synonym Full Names: FYVE, RhoGEF and PH domain containing 3
• NCBI Official Symbol: FGD3
• NCBI Official Synonym Symbols: ZFYVE5
• NCBI Protein Information: FYVE, RhoGEF and PH domain-containing protein 3; FGD1 family, member 3; faciogenital dysplasia 3; zinc finger FYVE domain-containing protein 5
• UniProt Protein Name: FYVE, RhoGEF and PH domain-containing protein 3
• Protein Family: FYVE, RhoGEF and PH domain-containing protein
• UniProt Gene Name: FGD3
• UniProt Synonym Gene Names: ZFYVE5
• UniProt Entry Name: FGD3_HUMAN

Uniprot Description

FGD3: Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rac/Rho

Chromosomal Location of Human Ortholog: -

Cellular Component: Golgi apparatus; ruffle; cytoskeleton; lamellipodium; cytoplasm; cytosol

Molecular Function: small GTPase binding; Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; metal ion binding

Biological Process: regulation of cell shape; regulation of small GTPase mediated signal transduction; filopodium formation; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction; cytoskeleton organization and biogenesis; actin cytoskeleton organization and biogenesis; positive regulation of GTPase activity