anti-Human Ferritin Polyclonal Antibody | anti-FTH1 antibody

Anti-Ferritin Rabbit pAb

Cat. Num. AAA475573

• Gene Names: FTH1; FHC; FTH; HFE5; PLIF; FTHL6; PIG15
• Reactivity: Human
• Applications: ELISA
• Purity: Affinity Purified
• Synonyms: Ferritin; Polyclonal Antibody; Anti-Ferritin Rabbit pAb; Apoferritin; Cell proliferation-inducing gene 15 protein; Ferritin H subunit; Ferritin heavy chain; Ferritin heavy chain like; Ferritin heavy polypeptide 1; Ferritin L chain; Ferritin L subunit; Ferritin light chain; Ferritin light chain like; Ferritin light polypeptide like 3; ferritin; heavy polypeptide 1; light polypeptide; FHC; FRIH_HUMAN; FTH; FTH1; FTHL6; FTL; FTL protein; HFE5; MGC104426; NBIA3; PIG15; Placenta immunoregulatory factor; PLIF; Proliferation inducing protein 15; anti-FTH1 antibody

• Host: Rabbit; Source: Human
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Affinity Purified
• Form/Format: PBS (pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
• Concentration: 9.17mg/ml (varies by lot)
• Sequence Length: 183

• Applicable Applications for anti-FTH1 antibody: ELISA (EIA)
• Immunogen: Recombinant protein of human Ferritin.
• Sensitivity: This antibody recognizes both, Ferritin heavy and light chains.
• Sequence Similarities: Belongs to the ferritin family. Contains 1 ferritin-like diiron domain.
• Subunit Structure: Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. In the human liver, the heavy chain is predominant. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

Testing Data

(Standard Curve for Ferritin: Capture Antibody Mouse mAb (201067, Ferritin Light Chain Mouse mAb) to Ferritin at 2mug/ml and Detector Antibody Rabbit pAb (3010667, Ferritin rabbit pAb)to Ferritin at 0.5mug/ml.)

Related Product Information for anti-FTH1 antibody

Entrez Summary: This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.
UniPort Summary Function: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells.

NCBI and Uniprot Product Information

• NCBI GI #: 56682959
• NCBI GeneID: 2495
• NCBI Accession #: NP_002023.2
• NCBI GenBank Nucleotide #: NM_002032.2
• UniProt Accession #: P02794; Q3KRA8; Q3SWW1; B3KNR5
• Molecular Weight: 21,226 Da
• NCBI Official Full Name: ferritin heavy chain
• NCBI Official Synonym Full Names: ferritin heavy chain 1
• NCBI Official Symbol: FTH1
• NCBI Official Synonym Symbols: FHC; FTH; HFE5; PLIF; FTHL6; PIG15
• NCBI Protein Information: ferritin heavy chain
• UniProt Protein Name: Ferritin heavy chain
• Protein Family: Ferritin
• UniProt Gene Name: FTH1
• UniProt Synonym Gene Names: FTH; FTHL6; Ferritin H subunit

NCBI Description

This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney ().