Rabbit anti-Human Feline Sarcoma Oncogene (FES) Polyclonal Antibody | anti-FES antibody
APC-Linked Polyclonal Antibody to Feline Sarcoma Oncogene (FES)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]
Uniprot Description
Fes: a non-receptor tyrosine kinase of the Fer family. Appears to be involved in normal hematopoiesis as well as the development of acute promyelocytic leukemia. Contains one SH2 and one FCH domain. Four LOF point mutations seen in colorectal cancer. Orthologous to v-fes from feline leukemia virus and v-fps from avian transforming virus. Mutant forms are angiogenic. Promotes survival during differentiation, and may act both to promote and inhibit tumors. May be disrupted in the t(15q+;17q-) found in acute promyelocytic leukemia, but the breakpoint does not occur within the gene.
Protein type: EC 2.7.10.2; Fer family; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tumor suppressor
Chromosomal Location of Human Ortholog: 15q26.1
Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; extrinsic to internal side of plasma membrane; focal adhesion; microtubule cytoskeleton
Molecular Function: non-membrane spanning protein tyrosine kinase activity; phosphoinositide binding; protein binding; protein-tyrosine kinase activity
Biological Process: cell proliferation; chemotaxis; epidermal growth factor receptor signaling pathway; innate immune response; multicellular organismal development; peptidyl-tyrosine phosphorylation; positive regulation of microtubule polymerization; positive regulation of myeloid cell differentiation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell adhesion; regulation of cell differentiation; regulation of cell proliferation; regulation of cell shape; regulation of mast cell degranulation
Research Articles on FES
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Product Notes
The FES fes (Catalog #AAA2080860) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The APC-Linked Polyclonal Antibody to Feline Sarcoma Oncogene (FES) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Feline Sarcoma Oncogene (FES) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA). Researchers should empirically determine the suitability of the FES fes for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Feline Sarcoma Oncogene (FES), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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