Rabbit FE65 Polyclonal Antibody | anti-FE65 antibody

FE65 Rabbit Polyclonal

Cat. Num. AAA769301

• Gene Names: Apbb1; FE65
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunofluorescence
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: FE65; Polyclonal Antibody; FE65 Rabbit Polyclonal; anti-FE65 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 711

• Applicable Applications for anti-FE65 antibody: ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
• Immunogen: Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(human brain tissue were subjected to SDS PAGE followed by western blot with MBS769301 (FE65 antibody) at dilution of 1:300)

NCBI and Uniprot Product Information

• NCBI GI #: 13377732
• NCBI GeneID: 29722
• Molecular Weight: 77,371 Da
• NCBI Official Full Name: FE65
• NCBI Official Synonym Full Names: amyloid beta precursor protein binding family B member 1
• NCBI Official Symbol: Apbb1
• NCBI Official Synonym Symbols: FE65
• NCBI Protein Information: amyloid beta A4 precursor protein-binding family B member 1
• UniProt Protein Name: Amyloid beta A4 precursor protein-binding family B member 1
• UniProt Gene Name: Apbb1
• UniProt Synonym Gene Names: Fe65
• UniProt Entry Name: APBB1_RAT

NCBI Description

displays in vitro binding to the NPTY intracellular domain of the Alzheimers disease associated human beta amyloid precursor protein [RGD, Feb 2006]

Uniprot Description

Fe65: adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on Y142 (H2AXpY142) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as TIP60, probably explains its trancription activation activity.

Protein type: Transcription regulation; Apoptosis; Adaptor/scaffold

Cellular Component: cell soma; cytoplasm; dendritic spine; growth cone; lamellipodium; nuclear speck; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic membrane; presynaptic membrane; protein complex; synapse

Molecular Function: beta-amyloid binding; chromatin binding; histone binding; protein binding; protein complex binding; tau protein binding; transcription factor binding

Biological Process: apoptosis; axon guidance; cell cycle arrest; double-strand break repair; extracellular matrix organization and biogenesis; negative regulation of cell growth; negative regulation of neuron differentiation; negative regulation of thymidylate synthase biosynthetic process; neuron migration; positive regulation of apoptosis; positive regulation of DNA repair; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to DNA damage stimulus; response to iron ion; transcription, DNA-dependent; visual learning