Immunohistochemistry (IHC)
(Immunochemical staining of mouse FDPS in mouse kidney with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections).)
Rabbit anti-Mouse FDPS Polyclonal Antibody | anti-FDPS antibody
Anti-FDPS Antibody, Rabbit Polyclonal
Reactivity
Mouse
Applications
Western Blot, Immunohistochemistry, Immunoprecipitation
Purity
Protein A & Antigen Affinity
Synonyms
FDPS; Polyclonal Antibody; Anti-FDPS Antibody; Rabbit Polyclonal; FDPS/Farnesyl Diphosphate Synthase Antibody; Rabbit PAb; Antigen Affinity Purified; farnesyl diphosphate synthase; Anti-6030492I17Rik Antibody; Anti-AI256750 Antibody; Anti-Fdpsl1 Antibody; Anti-mKIAA1293 Antibody; anti-FDPS antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Mouse FDPS/Farnesyl Diphosphate Synthase
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-FDPS antibody
Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P), Immunoprecipitation (IP)
Application Notes
WB: 1:500-1:2000
IHC-P: 1:1000-1:4000
IP: 1-4uL/mg of lysate
IHC-P: 1:1000-1:4000
IP: 1-4uL/mg of lysate
Immunogen
Recombinant Mouse FDPS/Farnesyl Diphosphate Synthase protein
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with purified, recombinant Mouse FDPS/Farnesyl Diphosphate Synthase. FDPS/Farnesyl Diphosphate Synthase specific IgG was purified by Mouse FDPS/Farnesyl Diphosphate Synthase affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of mouse FDPS in mouse kidney with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections).)
Immunohistochemistry (IHC)
(Immunochemical staining of mouse FDPS in mouse kidney with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections).)
Immunoprecipitation (IP)
(Mouse FDPS was immunoprecipitated using:Lane A:0.5 mg A549 Whole Cell LysateLane B:0.5 mg THP-1 Whole Cell Lysate2 uL anti-Mouse FDPS rabbit polyclonal antibody and 15 ul of 50 % Protein G agarose.Primary antibody:Anti-Mouse FDPS rabbit polyclonal antibody,at 1:200 dilution Secondary antibody:Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution Developed using the odssey technique.Performed under reducing conditions.Predicted band size: 38 kDaObserved band size: 38 kDa)
Immunoprecipitation (IP)
(Mouse FDPS was immunoprecipitated using:Lane A:0.5 mg A549 Whole Cell LysateLane B:0.5 mg THP-1 Whole Cell Lysate2 uL anti-Mouse FDPS rabbit polyclonal antibody and 15 ul of 50 % Protein G agarose.Primary antibody:Anti-Mouse FDPS rabbit polyclonal antibody,at 1:200 dilution Secondary antibody:Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution Developed using the odssey technique.Performed under reducing conditions.Predicted band size: 38 kDaObserved band size: 38 kDa)
Western Blot (WB)
(Anti-FDPS rabbit polyclonal antibody at 1:500 dilutionLane A: THP1 Whole Cell LysateLane B: HepG2 Whole Cell LysateLane C: A549 Whole Cell LysateLysates/proteins at 30 ug per lane.SecondaryGoat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.Developed using the Odyssey technique. Performed under reducing conditions.Predicted band size:48 kDaObserved band size:38 kDa(We are unsure as to the identity of these extra bands.))
Western Blot (WB)
(Anti-FDPS rabbit polyclonal antibody at 1:500 dilutionLane A: THP1 Whole Cell LysateLane B: HepG2 Whole Cell LysateLane C: A549 Whole Cell LysateLysates/proteins at 30 ug per lane.SecondaryGoat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.Developed using the Odyssey technique. Performed under reducing conditions.Predicted band size:48 kDaObserved band size:38 kDa(We are unsure as to the identity of these extra bands.))
Related Product Information for anti-FDPS antibody
Z-farnesyl diphosphate synthase (FDPS) is an enzyme belonging to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. Z-farnesyl diphosphate synthase (FDPS) functions as key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate, a precurcor for several classes of essential metabolites. FDPS catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Functions of FDPS may be inactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid rafts at the plasma membrane, and thus have an antiviral effect since many enveloped viruses need lipid rafts to bud efficiently out of the cell.
References
Pjetursson BE, et al. (2007) Comparison of survival and complication rates of tooth-supported fixed dental prostheses (FDPs) and implant-supported FDPs and single crowns (SCs). Clin Oral Implants Res. 3:97-113.Eschbach S, et al. (2009) Clinical evaluation of all-ceramic posterior three-unit FDPs made of In-Ceram Zirconia. Int J Prosthodont. 22(5):490-2.Moshage HJ, et al. (1990) Differential effects of endotoxin and fibrinogen degradation products (FDPS) on liver synthesis of fibrinogen and albumin: evidence for the involvement of a novel monokine in the stimulation of fibrinogen synthesis induced by FDPS. Int J Biochem. 22(12): 1393-400.
NCBI and Uniprot Product Information
Protein Family
Similar Products
Product Notes
The FDPS (Catalog #AAA8112417) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-FDPS Antibody, Rabbit Polyclonal reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's FDPS can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P), Immunoprecipitation (IP). WB: 1:500-1:2000 IHC-P: 1:1000-1:4000 IP: 1-4uL/mg of lysate. Researchers should empirically determine the suitability of the FDPS for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FDPS, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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