Rabbit FBXW11 Polyclonal Antibody | anti-FBXW11 antibody

FBXW11 Rabbit Polyclonal

Cat. Num. AAA769284

• Gene Names: FBXW11; Hos; BTRC2; FBW1B; Fbw11; BTRCP2; FBXW1B
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: FBXW11; Polyclonal Antibody; FBXW11 Rabbit Polyclonal; anti-FBXW11 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 542

• Applicable Applications for anti-FBXW11 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: F-box and WD repeat domain containing 11
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(SGC-7901 cells were subjected to SDS PAGE followed by western blot with MBS769284 (FBXW11 antibody) at dilution of 1:2000)

NCBI and Uniprot Product Information

• NCBI GI #: 48928050
• NCBI GeneID: 23291
• NCBI Accession #: NP_036432.2
• NCBI GenBank Nucleotide #: NM_012300.2
• Molecular Weight: 60,898 Da
• NCBI Official Full Name: F-box/WD repeat-containing protein 11 isoform C
• NCBI Official Synonym Full Names: F-box and WD repeat domain containing 11
• NCBI Official Symbol: FBXW11
• NCBI Official Synonym Symbols: Hos; BTRC2; FBW1B; Fbw11; BTRCP2; FBXW1B
• NCBI Protein Information: F-box/WD repeat-containing protein 11
• UniProt Protein Name: F-box/WD repeat-containing protein 11
• Protein Family: F-box/WD repeat-containing protein
• UniProt Gene Name: FBXW11
• UniProt Synonym Gene Names: BTRCP2; FBW1B; FBXW1B; KIAA0696; HOS
• UniProt Entry Name: FBW1B_HUMAN

NCBI Description

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]

Uniprot Description

FBW1B: a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex May participate in Wnt signaling. Three alternatively spliced isoforms have been described.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: centrosome; cytosol; nucleus; SCF ubiquitin ligase complex; ubiquitin ligase complex

Molecular Function: protein binding; protein dimerization activity; ubiquitin-protein ligase activity

Biological Process: G2/M transition of mitotic cell cycle; negative regulation of NF-kappaB import into nucleus; negative regulation of transcription, DNA-dependent; positive regulation of circadian rhythm; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid dephosphorylation; protein destabilization; protein polyubiquitination; protein ubiquitination; rhythmic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; T cell receptor signaling pathway; Wnt receptor signaling pathway