Rabbit FBXO7 Polyclonal Antibody | anti-FBXO7 antibody

FBXO7 Polyclonal Antibody

Cat. Num. AAA2537260

• Gene Names: FBXO7; FBX; FBX7; PKPS; FBX07; PARK15
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purification
• Synonyms: FBXO7; Polyclonal Antibody; FBXO7 Polyclonal Antibody; FBX; FBX7; PKPS; FBX07; PARK15; anti-FBXO7 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification

• Applicable Applications for anti-FBXO7 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:2000, IHC: 1:50-1:200
• Immunogen: Recombinant protein of human FBXO7
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-86450 / sc-86448
• Preparation and Storage: Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using FBXO7 antibody.)

Related Product Information for anti-FBXO7 antibody

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined.

NCBI and Uniprot Product Information

• NCBI GI #: 384229053
• NCBI GeneID: 25793
• NCBI Accession #: NP_001244919.1
• NCBI GenBank Nucleotide #: NM_001257990.1
• Molecular Weight: Calculated MW: 59kDa
• NCBI Official Full Name: F-box only protein 7 isoform 3
• NCBI Official Synonym Full Names: F-box protein 7
• NCBI Official Symbol: FBXO7
• NCBI Official Synonym Symbols: FBX; FBX7; PKPS; FBX07; PARK15
• NCBI Protein Information: F-box only protein 7
• UniProt Protein Name: F-box only protein 7
• Protein Family: F-box only protein
• UniProt Gene Name: FBXO7
• UniProt Synonym Gene Names: FBX7
• UniProt Entry Name: FBX7_HUMAN

NCBI Description

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined. [provided by RefSeq, Jul 2008]

Uniprot Description

FBXO7: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Defects in FBXO7 are the cause of Parkinson disease type 15 (PARK15); also known as parkinsonian-pyramidal syndrome. A neurodegenerative disorder characterized by parkinsonian and pyramidal signs. Clinical manifestations include tremor, bradykinesia, rigidity, postural instability, spasticity, mainly in the lower limbs, and hyperreflexia. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 22q12.3

Cellular Component: cytoplasm; cytosol; mitochondrion; nucleus; protein complex; ubiquitin ligase complex

Molecular Function: protein binding; protein kinase binding; ubiquitin-protein ligase activity

Biological Process: mitochondrion degradation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of lymphocyte differentiation; protein targeting to mitochondrion; protein ubiquitination; regulation of protein stability; ubiquitin-dependent protein catabolic process

Disease: Parkinson Disease 15, Autosomal Recessive Early-onset