Rabbit anti-Human FBXO46 Polyclonal Antibody | anti-FBXO46 antibody

FBXO46, CT (FBXO46, FBX46, FBXO34L, F-box only protein 46, F-box only protein 34-like) (FITC)

Cat. Num. AAA6298464

• Gene Names: FBXO46; Fbx46; FBXO34L; 20D7-FC4
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: FBXO46; Polyclonal Antibody; CT (FBXO46; FBX46; FBXO34L; F-box only protein 46; F-box only protein 34-like) (FITC); F-box only protein 34-like; anti-FBXO46 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-FBXO46 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: FBXO46 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 583-612 amino acids from the C-terminal region of human FBXO46.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(FBXO46 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the FBXO46 antibody detected the FBXO46 protein (arrow).)

Related Product Information for anti-FBXO46 antibody

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity).

Product Categories/Family for anti-FBXO46 antibody

Antibodies; Ubiquitin Ligases

NCBI and Uniprot Product Information

• NCBI GI #: 122937335
• NCBI GeneID: 23403
• NCBI Accession #: NP_001073938.1
• NCBI GenBank Nucleotide #: NM_001080469.1
• UniProt Accession #: Q6PJ61
• Molecular Weight: 64,631 Da
• NCBI Official Full Name: F-box only protein 46
• NCBI Official Synonym Full Names: F-box protein 46
• NCBI Official Symbol: FBXO46
• NCBI Official Synonym Symbols: Fbx46; FBXO34L; 20D7-FC4
• NCBI Protein Information: F-box only protein 46
• UniProt Protein Name: F-box only protein 46
• Protein Family: F-box only protein
• UniProt Gene Name: FBXO46
• UniProt Synonym Gene Names: FBX46; FBXO34L
• UniProt Entry Name: FBX46_HUMAN

NCBI Description

Members of the F-box protein family, such as FBXO46, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Uniprot Description

Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex

By similarity.

Subunit structure: Interacts with SKP1 and CUL1

By similarity.

Sequence similarities: Contains 1 F-box domain.

Caution: The region from 1 to 163 was deduced from the genomic sequence and ESTs by similarity to the mouse sequence.

Sequence caution: The sequence AAH21978.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAH21978.1 differs from that shown. Reason: Erroneous termination at position 604. Translated as stop.