Rabbit anti-Human, Mouse FBXL19 Polyclonal Antibody | anti-FBXL19 antibody

FBXL19, CT (FBXL19, FBL19, F-box/LRR-repeat protein 19, F-box and leucine-rich repeat protein 19) (AP)

Cat. Num. AAA6298263

• Gene Names: FBXL19; Fbl19; CXXC11; JHDM1C
• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: FBXL19; Polyclonal Antibody; CT (FBXL19; FBL19; F-box/LRR-repeat protein 19; F-box and leucine-rich repeat protein 19) (AP); F-box and leucine-rich repeat protein 19; anti-FBXL19 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-FBXL19 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: FBXL19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 542-570 amino acids from the C-terminal region of human FBXL19.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(FBXL19 Antibody (C-term) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the FBXL19 Antibody detected the FBXL19 protein (arrow).)

Related Product Information for anti-FBXL19 antibody

Members of the F-box protein family, such as FBXL19, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM].

Product Categories/Family for anti-FBXL19 antibody

Antibodies; Ubiquitin Ligases

References

Martin, J., et al. Nature 432(7020):988-994(2004). Katoh, M., et al. Int. J. Mol. Med. 14(6):1109-1114(2004). Jin, J., et al. Genes Dev. 18(21):2573-2580(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 157168349
• NCBI GeneID: 54620
• NCBI Accession #: NP_001093254.2
• NCBI GenBank Nucleotide #: NM_001099784.2
• UniProt Accession #: Q6PCT2; Q8N789; Q9NT14; A8MT10
• Molecular Weight: 75,707 Da
• NCBI Official Full Name: F-box/LRR-repeat protein 19 isoform 1
• NCBI Official Synonym Full Names: F-box and leucine-rich repeat protein 19
• NCBI Official Symbol: FBXL19
• NCBI Official Synonym Symbols: Fbl19; CXXC11; JHDM1C
• NCBI Protein Information: F-box/LRR-repeat protein 19; jumonji C domain-containing histone demethylase 1C
• UniProt Protein Name: F-box/LRR-repeat protein 19
• Protein Family: F-box/LRR-repeat protein
• UniProt Gene Name: FBXL19
• UniProt Synonym Gene Names: FBL19
• UniProt Entry Name: FXL19_HUMAN

Uniprot Description

FBXL19: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: SCF ubiquitin ligase complex

Molecular Function: DNA binding; zinc ion binding

Biological Process: proteasomal ubiquitin-dependent protein catabolic process