Rabbit anti-Human FBLN1 Polyclonal Antibody | anti-fbln1 antibody

FBLN1 (Fibulin 1, FBLN, Fibulin-1, FIBL-1, PP213)

Cat. Num. AAA6001111

• Gene Names: fbln1; fbln1c; fbln1d; wu:fc52c06
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: FBLN1; Polyclonal Antibody; FBLN1 (Fibulin 1; FBLN; Fibulin-1; FIBL-1; PP213); Anti -FBLN1 (Fibulin 1; anti-fbln1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human FBLN1.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MERAAPSRRVPLQLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGSNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKLPLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKMDLSRHGTVSSFVAKLFIFVSAEL

• Applicable Applications for anti-fbln1 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human FBLN1, aa1-683 (AAH22497.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of FBLN1 expression in transfected 293T cell line by FBLN1 polyclonal antibody. Lane 1: FBLN1 transfected lysate (74.4kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-fbln1 antibody

Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP.

Product Categories/Family for anti-fbln1 antibody

Antibodies; Abs to Membrane Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 18858663
• NCBI GeneID: 30240
• NCBI Accession #: NP_571117.1
• NCBI GenBank Nucleotide #: NM_131042.1
• UniProt Accession #: O42182; O42183
• Molecular Weight: 74,460 Da
• NCBI Official Full Name: fibulin-1
• NCBI Official Synonym Full Names: fibulin 1
• NCBI Official Symbol: fbln1
• NCBI Official Synonym Symbols: fbln1c; fbln1d; wu:fc52c06
• NCBI Protein Information: fibulin-1; FIBL-1; fibulin 1C; fibulin 1D
• UniProt Protein Name: Fibulin-1
• UniProt Gene Name: fbln1
• UniProt Synonym Gene Names: FIBL-1
• UniProt Entry Name: FBLN1_DANRE

Uniprot Description

Function: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.

Subunit structure: Homomultimerizes and interacts with various extracellular matrix components such as FN1, LAMA1, NID, AGC1 and CSPG2.

Subcellular location: Secreted › extracellular space › extracellular matrix.

Developmental stage: Isoform C is detected in the later blastula period, 4 hours after fertilization. Isoform D is not detected at this stage, it first appears during the gastrula period in 8 hours old embryos. Expression of both isoforms is then maintained throughout development. During later developmental stages, prominent expression is seen in regions where tissue compartments are continuously moving in relation to each other.

Sequence similarities: Belongs to the fibulin family.Contains 3 anaphylatoxin-like domains.Contains 9 EGF-like domains.