Rabbit anti-Human FBL6 Polyclonal Antibody | anti-FBL6 antibody

FBL6 antibody

Cat. Num. AAA9412886

• Gene Names: FBXL6; FBL6; FBL6A; PP14630
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Purified by antigen-affinity chromatography.
• Synonyms: FBL6; Polyclonal Antibody; FBL6 antibody; anti-FBL6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Purified by antigen-affinity chromatography.
• Form/Format: Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
• Sequence Length: 539

• Applicable Applications for anti-FBL6 antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: Western blotting: 1:500-1:3000; Immunohistochemistry: 1:100-1:250; Immunofluorescence: 1:100-1:200
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide contain a sequence corresponding to a region within amino acids 478 and 539 of Human FBXL6
• Target Name: FBL6
• Preparation and Storage: Store at -20 degree C for long term preservation (recommended). Store at 4 degree C for short term use.

Testing Data

(Sample(30 ug of whole cell lysate)A: HeLa S3 10% SDS PAGEPrimary antibody diluted at 1: 1500)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Thyroid Ca, using FBL6 antibody at 1: 100 dilution.)

Immunofluorescence (IF)

(Immunofluorescence analysis of methanol-fixed A431, using FBL6 antibody at 1: 500 dilution.)

Related Product Information for anti-FBL6 antibody

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq]

Product Categories/Family for anti-FBL6 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 525342655
• NCBI GeneID: 26233
• NCBI Accession #: NP_036294
• NCBI GenBank Nucleotide #: NM_012162.3
• Molecular Weight: 57,914 Da
• NCBI Official Full Name: F-box/LRR-repeat protein 6 isoform 1
• NCBI Official Synonym Full Names: F-box and leucine-rich repeat protein 6
• NCBI Official Symbol: FBXL6
• NCBI Official Synonym Symbols: FBL6; FBL6A; PP14630
• NCBI Protein Information: F-box/LRR-repeat protein 6
• UniProt Protein Name: F-box/LRR-repeat protein 6
• UniProt Gene Name: FBXL6
• UniProt Synonym Gene Names: FBL6
• UniProt Entry Name: FBXL6_HUMAN

NCBI Description

This gene encodes a member of a family of proteins that are characterized by an F-box motif. The encoded protein also contains leucine-rich repeats. F-box-containing proteins comprise one of the subunits of the SCF (SKP1-cullin-F-box) complex, which functions in phosphorylation-dependent ubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

FBXL6: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; Ligase

Chromosomal Location of Human Ortholog: 8q24.3

Molecular Function: ubiquitin-protein ligase activity

Biological Process: protein ubiquitination; proteolysis