Rabbit anti-Human Fatty Acid Binding Protein, Adipocyte Polyclonal Antibody | anti-FABP7 antibody

Fatty Acid Binding Protein, Adipocyte (AFABP, FABP4)

Cat. Num. AAA628198

• Gene Names: FABP7; MRG; BLBP; FABPB; B-FABP; DKFZp547J2313
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by Immunoaffinity chromatography.
• Synonyms: Fatty Acid Binding Protein; Adipocyte; Polyclonal Antibody; Adipocyte (AFABP; FABP4); Anti -Fatty Acid Binding Protein; anti-FABP7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: igG
• Specificity: Recognizes human FABP4.
• Purity/Purification: Affinity Purified; Purified by Immunoaffinity chromatography.
• Form/Format: Supplied as a lyophilized powder from PBS, pH 7.2. Reconstitute with 50ul sterile ddH2O.
• Sequence: MCDAFVGTWK LVSSENFDDY MKEVGVGFAT RKVAGMAKPN MIISVNGDVI TIKSESTFKN TEISFILGQE; FDEVTADDRK VKSTITLDGG VLVHVQKWDG KSTTIKRKRE DDKLVVECVM KGVTSTRVYE RA

• Applicable Applications for anti-FABP7 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Immunohistochemistry and Western Blot.
• Immunogen: Recombinant human FABP4 expressed in E. coli
• Preparation and Storage: -20 degree C

Related Product Information for anti-FABP7 antibody

Adipocyte fatty acid binding protein AFABP is a 15kD member of the intracellular fatty acid binding protein (FABP) family, which is known for the ability to bind fatty acids and related compounds (bile acids or retinoids) in an internal cavity. AFABP is expressed in a differentiation-dependent fashion in adipocytes and is a critical gene in the regulation of the biological function of these cells. In mice, targeted mutations in AFABP provide significant protection from hyperinsulinemia and insulin resistance in the context of both dietary and genetic obesity. Adipocytes obtained from AFABP-deficient mice also have reduced efficiency of lipolysis in vitro and in vivo, and these mice exhibited moderately improved systemic dyslipidemia. Recent studies also demonstrated AFABP expression in macrophages upon differentiation and activation. In these cells, AFABP modulates inflammatory responses and cholesterol ester accumulation, and total or macrophage-specific AFABP deficiency confers dramatic protection against atherosclerosis in the apoE-/- mice. These results indicate a central role for AFABP in the development of major components of the metabolic syndrome through its distinct actions in adipocytes and macrophages.

Product Categories/Family for anti-FABP7 antibody

Antibodies; Abs to Fatty Acid Binding Protein

NCBI and Uniprot Product Information

• NCBI GI #: 2645203
• NCBI GeneID: 2173
• UniProt Accession #: O15540; O14951; Q6IAU7; B2R4L1; Q9H047
• Molecular Weight: 14,889 Da
• NCBI Official Full Name: fatty acid binding protein
• NCBI Official Synonym Full Names: fatty acid binding protein 7, brain
• NCBI Official Symbol: FABP7
• NCBI Official Synonym Symbols: MRG; BLBP; FABPB; B-FABP; DKFZp547J2313
• NCBI Protein Information: fatty acid-binding protein, brain; OTTHUMP00000017118; OTTHUMP00000017119; brain lipid binding protein; brain lipid-binding protein; fatty acid-binding protein 7; brain-type fatty acid-binding protein; mammary-derived growth inhibitor related; mammary-derived growth inhibitor-related
• UniProt Protein Name: Fatty acid-binding protein, brain
• Protein Family: Fatty acid-binding protein
• UniProt Gene Name: FABP7
• UniProt Synonym Gene Names: BLBP; FABPB; MRG
• UniProt Entry Name: FABP7_HUMAN

NCBI Description

The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism. [provided by RefSeq]

Uniprot Description

FABP7: B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Protein type: Lipid-binding; Cell development/differentiation; Cell cycle regulation

Chromosomal Location of Human Ortholog: 6q22-q23

Cellular Component: cell projection; cell soma; cytoplasm; nucleus

Molecular Function: transporter activity; lipid binding

Biological Process: negative regulation of cell proliferation; nervous system development; epithelial cell proliferation; neurogenesis; prepulse inhibition; transport; cell proliferation in forebrain