Rabbit anti-Human Fatty Acid Amide Hydrolase Polyclonal Antibody | anti-FAAH antibody
Fatty Acid Amide Hydrolase (FAAH)
Gene Names
FAAH; FAAH-1; MGC102823; MGC138146; FAAH
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Affinity PurifiedPurified by immunoaffinity chromatography.
Synonyms
Fatty Acid Amide Hydrolase; Polyclonal Antibody; Fatty Acid Amide Hydrolase (FAAH); Anti -Fatty Acid Amide Hydrolase (FAAH); anti-FAAH antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human Fatty Acid Amide Hydrolase (FAAH). The immunogen shows no significant sequence homology with other hydrolases. Species Sequence Homology: rat-100%, mouse and porcine-94%, chicken-58%.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.1% BSA.
Applicable Applications for anti-FAAH antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes
Suitable for use in Western Blot and ELISA.
Dilution: Western Blot: 1-10ug/ml (using Chemiluminescence technique).
ELISA: 1:10,000-1:50,000 using 50-100ng F0019-68A control peptide/well.
Dilution: Western Blot: 1-10ug/ml (using Chemiluminescence technique).
ELISA: 1:10,000-1:50,000 using 50-100ng F0019-68A control peptide/well.
Immunogen
A 17 amino acid peptide sequence near the N-terminus of human FAAH (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Related Product Information for anti-FAAH antibody
Cannabinoids, a group of C21 compounds present in Cannabis sativa L., their carboxylic acids, analogs, and transformation products, are the active ingredients found in hasish and marihuana. (-)-trans-D9-tetrahydrocannabinol (D9-THC) is the major psychopharmacologically active component of Cannabis. Cannabis affects cognition and memory, euphoria and sedation, and antinociception (analgesia) without the respiratory depression problems associated with opioid analgesics. To date, two sub-types of the G-protein coupled cannabinoid receptor, CB1 and CB2, have been identified. The first brain-derived endogenous cannabinoids, an unsaturated fatty-acid ethanolamide, arachidonylethanolamide (AEA, also called anandamide) was found in brain. AEA has higher affinity for the CB1 than for the CB2. Neurons and astrocytes have been found to re-uptake and hydrolyse anandamide rapidly, resulting in the formation of arachidonic acid and ethanolamine. The uptake mechanism has been shown to be mediated by a saturable, selective, temperature-dependent and Na+-independent transporter. Anandamide hydrolysis is catalyzed by a membrane-bound amidohydrolase (called anandamide amidohydrolase or fatty acid amide hydrolase, FAAH). FAAH (rat/mouse/human 579aa; chromosome 1p34-p35; mol wt ~67 kD) sequence analyses suggest a single predicted transmembrane domain at the extreme N-terminus of the enzyme.
Product Categories/Family for anti-FAAH antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
63,066 Da
NCBI Official Full Name
fatty acid amide hydrolase
NCBI Official Synonym Full Names
fatty acid amide hydrolase
NCBI Official Symbol
FAAH
NCBI Official Synonym Symbols
FAAH-1; MGC102823; MGC138146; FAAH
NCBI Protein Information
fatty-acid amide hydrolase 1; oleamide hydrolase 1; anandamide amidohydrolase 1
UniProt Protein Name
Fatty-acid amide hydrolase 1
Protein Family
UniProt Gene Name
FAAH
UniProt Synonym Gene Names
FAAH1
UniProt Entry Name
FAAH1_HUMAN
NCBI Description
This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq]
Uniprot Description
FAAH: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. Homodimer. Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate. Inhibited by O-aryl carbamates and alpha-keto heterocytes. Belongs to the amidase family.
Protein type: Hydrolase; EC 3.5.1.99; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p35-p34
Cellular Component: cytoskeleton; cytoplasm; integral to membrane; endomembrane system
Molecular Function: fatty acid amide hydrolase activity; carbon-nitrogen ligase activity, with glutamine as amido-N-donor; acylglycerol lipase activity
Biological Process: fatty acid catabolic process
Disease: Polysubstance Abuse, Susceptibility To
Research Articles on FAAH
1. These findings, although preliminary, suggest that the FAAH cDNA gene variants may contribute to the susceptibility to mood disorders
2. There is an association of the mutant type group A358C and A358A of FAAH with a worse cardiovascular profile (weight, body mass index, waist circumference, insulin,TNF-alpha and adiponectin levels) than wild type group.
3. In patients with morbid obesity, the C358A polymorphism of FAAH was not associated with anthropometric parameters, biochemical markers or adipocytokine levels.
4. FAAH expression and hydrolysis activity in the colon decrease in children with slow transit constipation.
5. Genetic variability in FAAH is associated with dyslipidemia, independent of insulin response.
6. The underlying mechanism of these genetic effects may be enhanced neural response in reward areas of the brain in carriers of the CNR1 G allele and FAAH C/C genotype in response to marijuana cues.
7. The combined analysis of all 603 obesity families supported the idea of an association of two SNPs in FAAH (rs324420 and rs2295632) with early onset extreme obesity
8. results in 5,109 subjects suggest that fatty acid amide hydrolase(FAAH) Pro129Thr polymorphism may modestly contribute to class III adult obesity in the French population
9. Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
10. Very low or absent FAAH and high CB1 levels correspond with spontaneous miscarriage.
2. There is an association of the mutant type group A358C and A358A of FAAH with a worse cardiovascular profile (weight, body mass index, waist circumference, insulin,TNF-alpha and adiponectin levels) than wild type group.
3. In patients with morbid obesity, the C358A polymorphism of FAAH was not associated with anthropometric parameters, biochemical markers or adipocytokine levels.
4. FAAH expression and hydrolysis activity in the colon decrease in children with slow transit constipation.
5. Genetic variability in FAAH is associated with dyslipidemia, independent of insulin response.
6. The underlying mechanism of these genetic effects may be enhanced neural response in reward areas of the brain in carriers of the CNR1 G allele and FAAH C/C genotype in response to marijuana cues.
7. The combined analysis of all 603 obesity families supported the idea of an association of two SNPs in FAAH (rs324420 and rs2295632) with early onset extreme obesity
8. results in 5,109 subjects suggest that fatty acid amide hydrolase(FAAH) Pro129Thr polymorphism may modestly contribute to class III adult obesity in the French population
9. Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
10. Very low or absent FAAH and high CB1 levels correspond with spontaneous miscarriage.
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Product Notes
The FAAH faah (Catalog #AAA614482) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Fatty Acid Amide Hydrolase (FAAH) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Fatty Acid Amide Hydrolase can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot and ELISA. Dilution: Western Blot: 1-10ug/ml (using Chemiluminescence technique). ELISA: 1:10,000-1:50,000 using 50-100ng F0019-68A control peptide/well. Researchers should empirically determine the suitability of the FAAH faah for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Fatty Acid Amide Hydrolase, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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