Rabbit anti-Human FANCA Polyclonal Antibody | anti-FANCA antibody

FANCA, ID (FANCA, FAA, FACA, FANCH, Fanconi anemia group A protein) (PE)

Cat. Num. AAA6297976

• Gene Names: FANCA; FA; FA1; FAA; FAH; FA-H; FACA; FANCH
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: FANCA; Polyclonal Antibody; ID (FANCA; FAA; FACA; FANCH; Fanconi anemia group A protein) (PE); Fanconi anemia group A protein; anti-FANCA antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-FANCA antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: FANCA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 666-694 amino acids from the Central region of human FANCA.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(FANCA Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the FANCA antibody detected the FANCA protein (arrow).)

Related Product Information for anti-FANCA antibody

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia.

Product Categories/Family for anti-FANCA antibody

Antibodies; Fanconi Proteins

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010). Monsees, G.M., et al. Breast Cancer Res. Treat. (2010). In press: Eriksson, N., et al. PLoS Genet. 6 (6), E1000993 (2010): Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 66880553
• NCBI GeneID: 2175
• NCBI Accession #: NP_000126.2
• NCBI GenBank Nucleotide #: NM_000135.2
• UniProt Accession #: O15360; O75266; Q6PL10; Q92497; Q96H18; Q9UEA5; Q9UEL8; Q9UEL9; Q9UPK3; Q9Y6M2; A5D923
• Molecular Weight: 162,775 Da
• NCBI Official Full Name: Fanconi anemia group A protein isoform a
• NCBI Official Synonym Full Names: Fanconi anemia, complementation group A
• NCBI Official Symbol: FANCA
• NCBI Official Synonym Symbols: FA; FA1; FAA; FAH; FA-H; FACA; FANCH
• NCBI Protein Information: Fanconi anemia group A protein; Fanconi anemia, type 1; Fanconi anemia, complementation group H
• UniProt Protein Name: Fanconi anemia group A protein
• Protein Family: Fanconi anemia group A protein
• UniProt Gene Name: FANCA
• UniProt Synonym Gene Names: FAA; FACA; FANCH; Protein FACA
• UniProt Entry Name: FANCA_HUMAN

NCBI Description

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia. [provided by RefSeq, Jul 2008]

Uniprot Description

FANCA: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Defects in FANCA are a cause of Fanconi anemia (FA). FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 16q24.3

Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding

Biological Process: male gonad development; protein complex assembly; male meiosis; DNA repair; female gonad development; regulation of cell proliferation

Disease: Fanconi Anemia, Complementation Group A; Tracheoesophageal Fistula With Or Without Esophageal Atresia