Rabbit anti-Human FAM5C Polyclonal Antibody | anti-FAM5C antibody

FAM5C, NT (FAM5C, DBCCR1L, DBCCR1L1, Protein FAM5C, DBCCR1-like protein 1) (APC)

Cat. Num. AAA6297879

• Gene Names: BRINP3; FAM5C; DBCCR1L; DBCCR1L1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: FAM5C; Polyclonal Antibody; NT (FAM5C; DBCCR1L; DBCCR1L1; Protein FAM5C; DBCCR1-like protein 1) (APC); DBCCR1-like protein 1; anti-FAM5C antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-FAM5C antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: FAM5C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 47~76 amino acids from the N-terminal region of human FAM5C.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western blot analysis of FAM5C Antibody (N-term) in K562 cell line lysates (35ug/lane). FAM5C (arrow) was detected using the purified Pab.)

Product Categories/Family for anti-FAM5C antibody

Antibodies; FAM

References

Kuroiwa, T., et al. Oncol. Rep. 22(5):1005-1011(2009). Connelly, J.J., et al. BMC Med. Genet. 9, 33 (2008). Shorts-Cary, L., et al. Endocrinology 148(3):967-975(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 953953831
• NCBI GeneID: 339479
• NCBI Accession #: NP_001304117.1
• NCBI GenBank Nucleotide #: NM_001317188.1
• UniProt Accession #: Q76B58; O95726; Q2M330; B3KVP1; B7Z260
• Molecular Weight: 76,299 Da
• NCBI Official Full Name: BMP/retinoic acid-inducible neural-specific protein 3 isoform 2
• NCBI Official Synonym Full Names: BMP/retinoic acid inducible neural specific 3
• NCBI Official Symbol: BRINP3
• NCBI Official Synonym Symbols: FAM5C; DBCCR1L; DBCCR1L1
• NCBI Protein Information: BMP/retinoic acid-inducible neural-specific protein 3
• UniProt Protein Name: BMP/retinoic acid-inducible neural-specific protein 3
• UniProt Gene Name: BRINP3
• UniProt Synonym Gene Names: DBCCR1L; DBCCR1L1; FAM5C

NCBI Description

This gene is overexpressed in pituitary tumors but is underexpressed in tongue squamous cell carcinomas, ulcerative colitis, and peri-implantitis. Polymorphisms that increase expression of this gene have been shown to increase vascular inflammation, and an association of this gene with myocardial infarction has been demonstrated. Finally, hypermethylation of this gene may find usefulness as a biomarker for gastric cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Uniprot Description

Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development.