Western Blot (WB)
(Western blot analysis of FAM59A in rat liver tissue lysate with FAM59A antibody at (A) 1 and (B) 2 ug/mL.)
Rabbit FAM59A Polyclonal Antibody | anti-FAM59A antibody
FAM59A Antibody
Gene Names
GAREM; Gm944; FAM59A; C18orf11
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
Affinity chromatography purified via peptide column
Synonyms
FAM59A; Polyclonal Antibody; FAM59A Antibody; GAREM; Grb2-associated and regulator of ERK; MAPK; Gm944; C18orf11; anti-FAM59A antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
876
Applicable Applications for anti-FAM59A antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Immunogen Type
Peptide
Immunogen Description
Raised against a 19 amino acid peptide from near the carboxy terminus of human FAM59A.
Target Name
FAM59A
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of FAM59A in rat liver tissue lysate with FAM59A antibody at (A) 1 and (B) 2 ug/mL.)
Western Blot (WB)
(Western blot analysis of FAM59A in rat liver tissue lysate with FAM59A antibody at (A) 1 and (B) 2 ug/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of PLEKHM3 in human brain tissue with PLEKHM3 antibody at 5 ug/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of PLEKHM3 in human brain tissue with PLEKHM3 antibody at 5 ug/mL.)
Related Product Information for anti-FAM59A antibody
FAM59A, also known as GAREM, was initially identified through a mass spectroscoptic method that measures different phosphotyrosine states of proteins in response to different cell stimuli. FAM59A is a downstream molecule in the EGF signaling pathway that is tyrosine-phosphorylated, and this phosphorylation is needed for the binding of Grb2, an adaptor protein crucial to the transduction of growth signals from the plasma membrane to the nucleus. ERK activation in response to EGF stimulation is regulated by FAM59A in COS-7 and HeLa cells, and the overexpression of FAM59A stimulated cell proliferation and colony formation in soft agar, suggesting that FAM59A might be a critical protein with roles in ligand-mediated signaling pathway of the EGF receptor and the tumorigenesis of cells.
Product Categories/Family for anti-FAM59A antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
97,099 Da
NCBI Official Full Name
GRB2-associated and regulator of MAPK protein isoform 1
NCBI Official Synonym Full Names
GRB2 associated, regulator of MAPK1
NCBI Official Symbol
GAREM
NCBI Official Synonym Symbols
Gm944; FAM59A; C18orf11
NCBI Protein Information
GRB2-associated and regulator of MAPK protein
UniProt Protein Name
GRB2-associated and regulator of MAPK protein
UniProt Gene Name
GAREM
UniProt Synonym Gene Names
C18orf11; FAM59A
UniProt Entry Name
GAREM_HUMAN
NCBI Description
This gene encodes an adaptor protein which functions in the epidermal growth factor (EGF) receptor-mediated signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Description
GAREM: a protein of unknown function. Contains a predicted ATPase (AAA+ superfamily).
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 18q12.1
Cellular Component: plasma membrane
Molecular Function: protein binding
Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of cell division; positive regulation of cell proliferation
Research Articles on FAM59A
Similar Products
Product Notes
The FAM59A garem (Catalog #AAA9404701) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FAM59A Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's FAM59A can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the FAM59A garem for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FAM59A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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