Western Blot (WB)
(Western blot (WB) analysis of FAIM2 polyclonal antibody at 1:500 dilutionLaneA: BV2 whole cell lysateLaneB: U-87MG whole cell lysateLaneC: HEK293T whole cell lysate)
Rabbit anti-Human, Mouse FAIM2 Polyclonal Antibody | anti-FAIM2 antibody
FAIM2 polyclonal antibody
Gene Names
FAIM2; LFG; LFG2; NGP35; NMP35; TMBIM2
Reactivity
Human, Mouse
Applications
Western Blot
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE)
Synonyms
FAIM2; Polyclonal Antibody; FAIM2 polyclonal antibody; Protein lifeguard 2; Fas apoptotic inhibitory molecule 2; Neural membrane protein 35; Transmembrane BAX inhibitor motif-containing protein 2; KIAA0950; LFG; LFG2; NMP35; TMBIM2; anti-FAIM2 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
FAIM2 polyclonal antibody detects endogenous levels of FAIM2 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE)
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Applicable Applications for anti-FAIM2 antibody
Western Blot (WB)
Application Notes
WB: 1:500~1:1000
IHC: 1:50~1:200
IHC: 1:50~1:200
Preparation and Storage
Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Western Blot (WB)
(Western blot (WB) analysis of FAIM2 polyclonal antibody at 1:500 dilutionLaneA: BV2 whole cell lysateLaneB: U-87MG whole cell lysateLaneC: HEK293T whole cell lysate)
Western Blot (WB)
(Western blot (WB) analysis of FAIM2 polyclonal antibody at 1:500 dilutionLaneA: BV2 whole cell lysateLaneB: U-87MG whole cell lysateLaneC: HEK293T whole cell lysate)
Related Product Information for anti-FAIM2 antibody
FAIM2 (fas apoptotic inhibitory molecule 2), also known as LFG (protein lifeguard), TMBIM2 (transmembrane BAX inhibitor motif-containing protein 2) and NMP35 (neural membrane protein 35), is a 316 amino acid multipass membrane protein that uniquely protects cells from Fas-induced apoptosis. Though widely expressed, FAIM2 expression is highest in hippocampus. FAIM2 contains seven transmembrane domains and resembles Bax Inhibitor-1, another anti-apoptotic protein. Overexpression of FAIM2 results in decreased caspase activation and reduced incidence of programmed cell death. Though mechanistically related to the Fas signal, FAIM2 does not protect cells from apoptosis that is mediated by TNF-alpha signaling. FAIM2 specifically regulates apoptosis by binding to the FAS receptor.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
~36
NCBI Official Full Name
lifeguard
NCBI Official Synonym Full Names
Fas apoptotic inhibitory molecule 2
NCBI Official Symbol
FAIM2
NCBI Official Synonym Symbols
LFG; LFG2; NGP35; NMP35; TMBIM2
NCBI Protein Information
protein lifeguard 2; neural membrane protein 35; transmembrane BAX inhibitor motif-containing protein 2
UniProt Protein Name
Protein lifeguard 2
Protein Family
UniProt Gene Name
FAIM2
UniProt Synonym Gene Names
KIAA0950; LFG; LFG2; NMP35; TMBIM2
UniProt Entry Name
LFG2_HUMAN
Uniprot Description
FAIM2: Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. Belongs to the BI1 family. LFG subfamily.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Apoptosis
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: postsynaptic membrane; integral to membrane; cell junction; lipid raft
Biological Process: apoptosis; cerebellar granular layer development; regulation of neuron apoptosis; cerebellar Purkinje cell differentiation; cerebellar Purkinje cell layer development; cerebellum development; negative regulation of neuron apoptosis; negative regulation of apoptosis
Research Articles on FAIM2
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Product Notes
The FAIM2 faim2 (Catalog #AAA3014821) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FAIM2 polyclonal antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's FAIM2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500~1:1000 IHC: 1:50~1:200. Researchers should empirically determine the suitability of the FAIM2 faim2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FAIM2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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