Western Blot (WB)
(Western Blot analysis of Mouse kidney, Mouse brain, Mouse spleen, Mouse lung with Phospho-FADD (Ser194) Polyclonal Antibody at dilution of 1:1000)
Rabbit anti-Human, Mouse FADD Polyclonal Antibody | anti-FADD antibody
Phospho-FADD (Ser194) Polyclonal Antibody
IHC: 1:100-1:300
ELISA: 1:5000
Western Blot (WB)
(Western Blot analysis of Mouse kidney, Mouse brain, Mouse spleen, Mouse lung with Phospho-FADD (Ser194) Polyclonal Antibody at dilution of 1:1000)
Western Blot (WB)
(Western Blot analysis of Mouse kidney, Mouse brain, Mouse spleen, Mouse lung with Phospho-FADD (Ser194) Polyclonal Antibody at dilution of 1:1000)
NCBI and Uniprot Product Information
Observed Molecular Weight: 28kDa
NCBI Description
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
Uniprot Description
FADD: an adaptor molecule that mediates apoptosis. Recruited through its C-terminal death domain by Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TRAIL-receptor, participating in the death signaling initiated by these receptors. Interaction with the receptors unmasks the N-terminal effector domain of this protein, which recruits caspase-8, and thereby activates the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Protein type: Adaptor/scaffold; Apoptosis
Chromosomal Location of Human Ortholog: 11q13.3
Cellular Component: CD95 death-inducing signaling complex; cell body; cytoplasm; cytosol; membrane raft; neuron projection; nucleus; plasma membrane
Molecular Function: caspase binding; death receptor binding; identical protein binding; protease binding; protein binding; protein complex binding; receptor serine/threonine kinase binding; tumor necrosis factor receptor binding; tumor necrosis factor receptor superfamily binding
Biological Process: activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; apoptosis; behavioral response to cocaine; cell surface receptor signaling pathway; death-inducing signaling complex assembly; defense response to virus; induction of apoptosis via death domain receptors; innate immune response; lymph node development; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of activated T cell proliferation; positive regulation of adaptive immune response; positive regulation of apoptosis; positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interferon-gamma production; positive regulation of interleukin-8 production; positive regulation of macrophage differentiation; positive regulation of proteolysis; positive regulation of T cell mediated cytotoxicity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; regulation of extrinsic apoptotic signaling pathway via death domain receptors; response to morphine; spleen development; T cell differentiation in thymus; T cell homeostasis; thymus development; toll-like receptor 3 signaling pathway; TRAIL-activated apoptotic signaling pathway; viral process
Disease: Infections, Recurrent, With Encephalopathy, Hepatic Dysfunction, And Cardiovascular Malformations
Research Articles on FADD
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Product Notes
The FADD fadd (Catalog #AAA2548834) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Phospho-FADD (Ser194) Polyclonal Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's FADD can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, ELISA (EIA). WB: 1:500-1:2000 IHC: 1:100-1:300 ELISA: 1:5000. Researchers should empirically determine the suitability of the FADD fadd for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FADD, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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