Western Blot (WB)
(Anti- Factor VII antibody, MBS176090, Western blottingAll lanes: Anti Factor VII (MBS176090) at 0.5ug/mlLane 1: SMMC Whole Cell Lysate at 40ugLane 2: JURKAT Whole Cell Lysate at 40ugLane 3: RAJI Whole Cell Lysate at 40ugPredicted bind size: 52KDObserved bind size: 52KD )
Rabbit anti-Human Factor VII Polyclonal Antibody | anti-F7 antibody
Anti-Factor VII antibody
Western Blot (WB)
(Anti- Factor VII antibody, MBS176090, Western blottingAll lanes: Anti Factor VII (MBS176090) at 0.5ug/mlLane 1: SMMC Whole Cell Lysate at 40ugLane 2: JURKAT Whole Cell Lysate at 40ugLane 3: RAJI Whole Cell Lysate at 40ugPredicted bind size: 52KDObserved bind size: 52KD )
Western Blot (WB)
(Anti- Factor VII antibody, MBS176090, Western blottingAll lanes: Anti Factor VII (MBS176090) at 0.5ug/mlLane 1: SMMC Whole Cell Lysate at 40ugLane 2: JURKAT Whole Cell Lysate at 40ugLane 3: RAJI Whole Cell Lysate at 40ugPredicted bind size: 52KDObserved bind size: 52KD )
Background: F7(Coagulation Factor VII), also known as proconvertin, is one of the proteins that causes blood to clot in the coagulation cascade. It is an enzyme of the serine protease class. The F7 gene maps to chromosome 13q34(Millar et al., 2000). Synthesis of factors VII and X, as well as factors II and IX, takes place in the liver and requires vitamin K. Structural homologies of these factors, which are precursors of serine proteases, have been shown(Zur and Nemerson, 1981). Di Bitondo et al.(2002) used reporter gene analysis to show that inclusion of promoter regions of F7 reduced transcription activity in the presence of estrogenic factors. The effect was independent of promoter polymorphic haplotype.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Uniprot Description
F7: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. Defects in F7 are the cause of factor VII deficiency (FA7D). A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Secreted, signal peptide; Secreted; Protease; Motility/polarity/chemotaxis; EC 3.4.21.21
Chromosomal Location of Human Ortholog: 13q34
Cellular Component: extracellular space; endoplasmic reticulum lumen; Golgi lumen; plasma membrane; extracellular region; vesicle
Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity; calcium ion binding; glycoprotein binding; receptor binding
Biological Process: circadian rhythm; positive regulation of protein kinase B signaling cascade; organ regeneration; blood coagulation, extrinsic pathway; cellular protein metabolic process; positive regulation of positive chemotaxis; positive regulation of blood coagulation; response to vitamin K; response to estrogen stimulus; positive regulation of leukocyte chemotaxis; post-translational protein modification; proteolysis; blood coagulation; peptidyl-glutamic acid carboxylation; positive regulation of cell migration
Disease: Myocardial Infarction, Susceptibility To; Factor Vii Deficiency
Research Articles on F7
Similar Products
Product Notes
The F7 f7 (Catalog #AAA176090) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Factor VII antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Factor VII can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the F7 f7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Factor VII, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
