Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Mouse Factor Related Apoptosis (FAS) Polyclonal Antibody | anti-FAS antibody
Polyclonal Antibody to Factor Related Apoptosis (FAS)
MGHHHHHHSGS-KYR KRKCWKRRQD DPESRTSSRE TIPMNASNLS LSKYIPRIAE DMTIQEAKKF ARENNIKEGK IDEIMHDSIQ DTAEQKVQLL LCWYQSHGKS DAYQDLIKGL KKAECRRTLD KFQDMVQKDL GKSTPDTGN
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded Liver tissue))
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded Liver tissue))
NCBI and Uniprot Product Information
Uniprot Description
FAS: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. Interacts with FADD. Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Cell surface; Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 19 C1|19 29.48 cM
Cellular Component: apical plasma membrane; CD95 death-inducing signaling complex; cell soma; cell surface; cytoplasm; cytosol; external side of plasma membrane; extracellular exosome; extracellular region; extracellular space; integral component of membrane; integral component of plasma membrane; membrane; membrane raft; mitochondrion; neuron projection; nuclear body; perinuclear region of cytoplasm; plasma membrane; sarcolemma; secretory granule
Molecular Function: calmodulin binding; identical protein binding; kinase binding; protease binding; protein binding; protein complex binding; transmembrane receptor activity; tumor necrosis factor binding; tumor necrosis factor-activated receptor activity
Biological Process: activated T cell apoptosis; apoptosis; B cell mediated immunity; cellular response to amino acid starvation; cellular response to hyperoxia; cellular response to lithium ion; circadian rhythm; dendrite regeneration; gene expression; immune response; immunoglobulin production; induction of apoptosis via death domain receptors; inflammatory cell apoptotic process; inflammatory response; negative regulation of apoptosis; negative regulation of B cell activation; negative thymic T cell selection; neuron apoptosis; positive regulation of apoptosis; positive regulation of apoptotic signaling pathway; positive regulation of cell death; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of neuron apoptotic process; positive regulation of protein homooligomerization; positive regulation of protein phosphorylation; positive regulation of release of cytochrome c from mitochondria; protein homooligomerization; regulation of apoptosis; regulation of cell proliferation; regulation of gene expression; regulation of lymphocyte differentiation; regulation of myeloid cell differentiation; regulation of stress-activated MAPK cascade; renal system process; response to glucocorticoid stimulus; response to lipopolysaccharide; response to toxin; signal transduction; spleen development; T cell homeostasis
Research Articles on FAS
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Product Notes
The FAS fas (Catalog #AAA2005494) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Factor Related Apoptosis (FAS) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Factor Related Apoptosis (FAS) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the FAS fas for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSG S-KYR KRKCWKRRQD DPESRTSSRE TIPMNASNLS LSKYIPRIAE DMTIQEAKKF ARENNIKEGK IDEIMHDSIQ DTAEQKVQLL LCWYQSHGKS DAYQDLIKGL KKAECRRTLD KFQDMVQKDL GKSTPDTGN. It is sometimes possible for the material contained within the vial of "Factor Related Apoptosis (FAS), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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