Sheep anti-Human F9 / Factor IX Polyclonal Antibody | anti-F9 antibody

Sheep Polyclonal (IgG) to Human F9 / Factor IX

Cat. Num. AAA244865

• Gene Names: F9; FIX; P19; PTC; HEMB; THPH8
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Ammonium sulfate precipitation
• Synonyms: F9 / Factor IX; Polyclonal Antibody; Sheep Polyclonal (IgG) to Human F9 / Factor IX; Anti-F9 / Factor IX Antibody IHC-plus; F9; Christmas Disease; Coagulation factor IX; Factor IX Deficiency; FIX; HEMB; F9 p22; Factor 9; Factor IX; Factor IX F9; FIX F9; Haemophilia B; THPH8; Christmas factor; Hemophilia B; PTC; Serine protease; Human F9; anti-F9 antibody

• Host: Sheep
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Factor IX as demonstrated by immunodiffusion. A single positive reactivity band was observed with Normal Human Plasma. No reaction was observed against F. IX-deficient plasma.
• Purity/Purification: Ammonium sulfate precipitation
• Form/Format: 0.01 M HEPES, pH 7.4, 0.1 M sodium chloride, 50% glycerol.
• Concentration: 10 mg/ml (varies by lot)
• Sequence Length: 461

• Applicable Applications for anti-F9 antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA), Immunoelectrophoresis
• Application Notes: ELISA, IE, IHC-P (5 ug/ml); Usage: Suitable for use in ELISA and Immunoelectrophoresis.
• Target Species: Human
• Immunogen Description: Human Factor IX (F. IX) purified from plasma.
• Immunogen: F9 / Factor IX antibody was raised against human Factor IX (F. IX) purified from plasma.
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

Immunohistochemistry (IHC)

(Anti-F9 / Factor IX antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Related Product Information for anti-F9 antibody

Coagulation Factor IX (F9) circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII.

Product Categories/Family for anti-F9 antibody

Family: Protease; Subfamily: Serine S1

NCBI and Uniprot Product Information

• NCBI GI #: 4503649
• NCBI GeneID: 2158
• NCBI Accession #: NP_000124.1
• NCBI GenBank Nucleotide #: NM_000133.3
• UniProt Accession #: P00740; Q5FBE1; Q5JYJ8; A8K9N4; F2RM36
• Molecular Weight: 47,618 Da
• NCBI Official Full Name: coagulation factor IX preproprotein
• NCBI Official Synonym Full Names: coagulation factor IX
• NCBI Official Symbol: F9
• NCBI Official Synonym Symbols: FIX; P19; PTC; HEMB; THPH8
• NCBI Protein Information: coagulation factor IX; F9 p22; FIX F9; factor 9; factor IX F9; Christmas factor; plasma thromboplastic component; plasma thromboplastin component
• UniProt Protein Name: Coagulation factor IX
• Protein Family: Coagulation factor
• UniProt Gene Name: F9
• UniProt Synonym Gene Names: PTC
• UniProt Entry Name: FA9_HUMAN

NCBI Description

This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. [provided by RefSeq, Jul 2008]

Uniprot Description

F9: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB); also known as Christmas disease. Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide. Defects in F9 are the cause of thrombophilia due to factor IX defect (THPH8). A hemostatic disorder characterized by a tendency to thrombosis. Belongs to the peptidase S1 family.

Protein type: Protease; EC 3.4.21.22; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: Xq27.1-q27.2

Cellular Component: endoplasmic reticulum lumen; Golgi lumen; plasma membrane; extracellular region

Molecular Function: serine-type endopeptidase activity; calcium ion binding

Biological Process: blood coagulation, extrinsic pathway; cellular protein metabolic process; post-translational protein modification; proteolysis; blood coagulation; blood coagulation, intrinsic pathway; peptidyl-glutamic acid carboxylation

Disease: Hemophilia B; Thrombophilia, X-linked, Due To Factor Ix Defect; Coumarin Resistance