Western Blot (WB)
(Western blot analysis of extracts from K562 cells treated with Na3VO4 using Phospho-Ezrin (Tyr478) antibody.The lane on the right is treated with the antigen-specific peptide.)
Rabbit anti-Human Ezrin Polyclonal Antibody | anti-EZR antibody
Ezrin (Phospho-Tyr478) Antibody
Western Blot (WB)
(Western blot analysis of extracts from K562 cells treated with Na3VO4 using Phospho-Ezrin (Tyr478) antibody.The lane on the right is treated with the antigen-specific peptide.)
Western Blot (WB)
(Western blot analysis of extracts from K562 cells treated with Na3VO4 using Phospho-Ezrin (Tyr478) antibody.The lane on the right is treated with the antigen-specific peptide.)
NCBI and Uniprot Product Information
NCBI Description
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
Ezrin: a member of the ERM family which includes radixin and moesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Plays a key role in cell surface structure adhesion, migration, and organization.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal
Chromosomal Location of Human Ortholog: 6q25.3
Cellular Component: cortical cytoskeleton; extracellular space; focal adhesion; microvillus; basolateral plasma membrane; T-tubule; actin filament; cytosol; actin cytoskeleton; lipid raft; ruffle; extrinsic to membrane; membrane; apical part of cell; microvillus membrane; apical plasma membrane; nucleolus; plasma membrane; uropod; vesicle; filopodium
Molecular Function: actin filament binding; protein domain specific binding; protein binding; cell adhesion molecule binding
Biological Process: axon guidance; regulation of cell shape; microvillus biogenesis; actin filament bundle formation; leukocyte adhesion; filopodium formation; cytoskeletal anchoring; receptor internalization; membrane to membrane docking; establishment of epithelial cell polarity
Research Articles on EZR
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Product Notes
The EZR ezr (Catalog #AAA9404393) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Ezrin (Phospho-Tyr478) Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Ezrin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blotting: 1:500~1:1000. Researchers should empirically determine the suitability of the EZR ezr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Ezrin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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