Rabbit Exportin-4 Polyclonal Antibody | anti-XPO4 antibody

Exportin-4 Polyclonal Antibody

Cat. Num. AAA668085

• Gene Names: XPO4; exp4
• Reactivity: Human (Predicted Reactivity: Mouse, Rat
• Applications: Western Blot
• Synonyms: Exportin-4; Polyclonal Antibody; Exportin-4 Polyclonal Antibody; anti-XPO4 antibody

• Host: Rabbit
• Reactivity: Human (Predicted Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Form/Format: Purified (Liquid)
• Concentration: 0.5mg/ml, 200µl (varies by lot)
• Sequence Length: 1151

• Applicable Applications for anti-XPO4 antibody: Western Blot (WB)
• Application Notes: Western Blot: 1-3 µg/ml
• Antigen: Exportin-4
• Immunogen: A partial recombinant Exportin-4 protein (amino acids 775-1,000) was used as the immunogen for this antibody.
• Preparation and Storage: Store antibody at 4 degree C, stable for 6 months. For long-term storage, store at -20 degree C. Avoid repeated freeze and thaw cycles. Expire 1 year from date of purchase.

Western Blot (WB)

( Expression analysis of Exportin-4. Anti- Exportin-4 antibody (11-8014) was used at 1 µg/ml on Heart lysate. )

Product Categories/Family for anti-XPO4 antibody

Cell signalling

NCBI and Uniprot Product Information

• NCBI GI #: 148886661
• NCBI GeneID: 64328
• NCBI Accession #: NP_071904.4
• NCBI GenBank Nucleotide #: NM_022459.4
• UniProt Accession #: Q9C0E2; Q5VUZ5; Q8N3V6; Q9H934
• Molecular Weight: 130,139 Da
• NCBI Official Full Name: exportin-4
• NCBI Official Synonym Full Names: exportin 4
• NCBI Official Symbol: XPO4
• NCBI Official Synonym Symbols: exp4
• NCBI Protein Information: exportin-4
• UniProt Protein Name: Exportin-4
• Protein Family: Exportin
• UniProt Gene Name: XPO4
• UniProt Synonym Gene Names: KIAA1721; Exp4
• UniProt Entry Name: XPO4_HUMAN

NCBI Description

XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009]

Uniprot Description

Exportin-4: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the exportin family.

Protein type: Nuclear export; Karyopherin

Chromosomal Location of Human Ortholog: 13q11

Cellular Component: nucleoplasm; cytoplasm

Molecular Function: protein binding

Biological Process: positive regulation of protein export from nucleus; protein transport