Rabbit anti-Human EXOSC7 Polyclonal Antibody | anti-EXOSC7 antibody

EXOSC7 Rabbit Polyclonal

Cat. Num. AAA769138

• Gene Names: EXOSC7; p8; EAP1; RRP42; Rrp42p; hRrp42p
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: EXOSC7; Polyclonal Antibody; EXOSC7 Rabbit Polyclonal; anti-EXOSC7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 291

• Applicable Applications for anti-EXOSC7 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Exosome component 7
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human colon tissue slide using MBS769138 (EXOSC7 Antibody) at dilution of 1:50)

Western Blot (WB)

(MCF-7 cells were subjected to SDS PAGE followed by western blot with MBS769138 (EXOSC7 Antibody) at dilution of 1:600)

NCBI and Uniprot Product Information

• NCBI GI #: 189083688
• NCBI GeneID: 23016
• NCBI Accession #: NP_055819.2
• NCBI GenBank Nucleotide #: NM_015004.3
• Molecular Weight: 31,821 Da
• NCBI Official Full Name: exosome complex component RRP42
• NCBI Official Synonym Full Names: exosome component 7
• NCBI Official Symbol: EXOSC7
• NCBI Official Synonym Symbols: p8; EAP1; RRP42; Rrp42p; hRrp42p
• NCBI Protein Information: exosome complex component RRP42
• UniProt Protein Name: Exosome complex component RRP42
• Protein Family: Exosome complex exonuclease
• UniProt Gene Name: EXOSC7
• UniProt Synonym Gene Names: KIAA0116; RRP42
• UniProt Entry Name: EXOS7_HUMAN

Uniprot Description

EXOSC7: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. Belongs to the RNase PH family.

Protein type: Ribonuclease; Nucleolus; RNA processing; EC 3.1.13.-

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: cytosol; exosome (RNase complex); nuclear exosome (RNase complex); nucleolus; nucleoplasm; nucleus

Molecular Function: 3'-5'-exoribonuclease activity; AU-rich element binding; exoribonuclease activity; protein binding; RNA binding

Biological Process: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); regulation of mRNA stability; RNA catabolic process; rRNA processing