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Western Blot (WB) (Western blot analysis of extracts from HeLa cells, Jurkat cells and HUVEC cells, using ES8L2 antibody.)

Rabbit anti-Human, Mouse ES8L2 Polyclonal Antibody | anti-ES8L2 antibody

ES8L2 Antibody

Gene Names
EPS8L2; EPS8R2
Reactivity
Human, Mouse
Applications
Western Blot
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms
ES8L2; Polyclonal Antibody; ES8L2 Antibody; Epidermal growth factor receptor kinase substrate 8-like protein 2; Epidermal growth factor receptor pathway substrate 8-related protein 2; EPS8-like protein 2; EPS8L2; EPS8R2; anti-ES8L2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total ES8L2 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
715
Applicable Applications for anti-ES8L2 antibody
Western Blot (WB)
Application Notes
Western blotting: 1:500~1:3000
Immunogen Type
Peptide
Immunogen Description
Synthesized peptide derived from internal of human ES8L2.
Target Name
ES8L2
Preparation and Storage
Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts from HeLa cells, Jurkat cells and HUVEC cells, using ES8L2 antibody.)

Western Blot (WB) (Western blot analysis of extracts from HeLa cells, Jurkat cells and HUVEC cells, using ES8L2 antibody.)
Related Product Information for anti-ES8L2 antibody
Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.Tocchetti A., Genomics 81:234-244(2003).Wan D., Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).Offenhaeuser N., Mol. Biol. Cell 15:91-98(2004).
Product Categories/Family for anti-ES8L2 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
82,323 Da
NCBI Official Full Name
epidermal growth factor receptor kinase substrate 8-like protein 2
NCBI Official Synonym Full Names
EPS8-like 2
NCBI Official Symbol
EPS8L2
NCBI Official Synonym Symbols
EPS8R2
NCBI Protein Information
epidermal growth factor receptor kinase substrate 8-like protein 2
UniProt Protein Name
Epidermal growth factor receptor kinase substrate 8-like protein 2
UniProt Gene Name
EPS8L2
UniProt Synonym Gene Names
EPS8R2; EPS8-like protein 2; EPS8-related protein 2
UniProt Entry Name
ES8L2_HUMAN

NCBI Description

This gene encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling. [provided by RefSeq, Dec 2008]

Uniprot Description

EPS8L2: Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. Belongs to the EPS8 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding; GEFs, Rac/Rho; GEFs

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: protein complex; cytoplasm; plasma membrane; vesicle

Molecular Function: Rho guanyl-nucleotide exchange factor activity; Rac guanyl-nucleotide exchange factor activity; actin binding

Biological Process: regulation of Rho protein signal transduction; Rho protein signal transduction

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Product Notes

The ES8L2 eps8l2 (Catalog #AAA9407581) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ES8L2 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's ES8L2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blotting: 1:500~1:3000. Researchers should empirically determine the suitability of the ES8L2 eps8l2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ES8L2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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