Rabbit ERP44 Polyclonal Antibody | anti-ERP44 antibody

Rabbit Polyclonal to Human ERP44

Cat. Num. AAA247458

• Gene Names: ERP44; PDIA10; TXNDC4
• Reactivity: Bat, Gibbon, Bovine, Chimpanzee, Chicken, Dog, Xenopus, Guinea pig, Gorilla, Horse, Human, Monkey, Mouse, Orangutan, Pig, Rabbit, Rat; Predicted Reactivity: Zebrafish (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: ERP44; Polyclonal Antibody; Rabbit Polyclonal to Human ERP44; Anti-ERP44 Antibody (Internal) IHC-plus; ER protein 44; PDIA10; TXNDC4; KIAA0573; Human ERP44; anti-ERP44 antibody

• Host: Rabbit
• Reactivity: Bat, Gibbon, Bovine, Chimpanzee, Chicken, Dog, Xenopus, Guinea pig, Gorilla, Horse, Human, Monkey, Mouse, Orangutan, Pig, Rabbit, Rat; Predicted Reactivity: Zebrafish (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human ERP44 / TXNDC4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 406

• Applicable Applications for anti-ERP44 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (15 - 20 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 20 amino acid peptide from internal region of human ERP44 / TXNDC4.
• Immunogen Type: Synthetic peptide
• Immunogen: ERP44 antibody was raised against synthetic 20 amino acid peptide from internal region of human ERP44 / TXNDC4. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Elephant, Panda, Dog, Bat, Bovine, Horse, Rabbit, Pig, Guinea pig, Turkey, Zebra finch, Chicken, Platypus, Lizard, Xenopus (100%); Opossum, Stickleback, Medaka, Pufferfish, Zebrafish (95%).
• Antigen Modification: Internal
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-ERP44 / TXNDC4 antibody IHC of human stomach. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-ERP44 / TXNDC4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-ERP44 antibody

TXNDC4/ERp44/KIAA0573 was identified via its interaction with Erol-Lalpha, which in turn has been shown to regulate oxidative protein folding by selectively oxidizing protein disulfide isomerase. TXNDC4 is induced during ER stress and forms mixed disulfides with both hEROs and cargo folding intermediates. Over expression has been shown to alter the equilibrium of the different Ero1-Lalpha redox isoforms suggesting that TXNDC4 may be involved in the control of oxidative protein folding.

NCBI and Uniprot Product Information

• NCBI GI #: 52487191
• NCBI GeneID: 23071
• NCBI Accession #: NP_055866.1
• NCBI GenBank Nucleotide #: NM_015051.1
• UniProt Accession #: Q9BS26; O60319; Q4VXC1; Q5VWZ7; Q6UW14; Q8WX67
• Molecular Weight: 46,971 Da
• NCBI Official Full Name: endoplasmic reticulum resident protein 44
• NCBI Official Synonym Full Names: endoplasmic reticulum protein 44
• NCBI Official Symbol: ERP44
• NCBI Official Synonym Symbols: PDIA10; TXNDC4
• NCBI Protein Information: endoplasmic reticulum resident protein 44; ER protein 44; thioredoxin domain-containing protein 4; endoplasmic reticulum resident protein 44 kDa; protein disulfide isomerase family A, member 10; thioredoxin domain containing 4 (endoplasmic reticulum)
• UniProt Protein Name: Endoplasmic reticulum resident protein 44
• Protein Family: Endoplasmic reticulum resident protein
• UniProt Gene Name: ERP44
• UniProt Synonym Gene Names: KIAA0573; TXNDC4; ER protein 44; ERp44
• UniProt Entry Name: ERP44_HUMAN

Uniprot Description

ERP44: Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum. Forms mixed disulfides with both ERO1L and ERO1LB and cargo folding intermediates. Directly interacts with ITPR1 in a pH-, redox state- and calcium-dependent manner, but not with ITPR2 or ITPR3. The strength of this interaction inversely correlates with calcium concentration. By endoplasmic reticulum stress.

Protein type: Secreted; Isomerase; Endoplasmic reticulum; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q31.1

Cellular Component: endoplasmic reticulum membrane; cell surface; endoplasmic reticulum lumen; ER-Golgi intermediate compartment

Molecular Function: protein binding; protein disulfide isomerase activity

Biological Process: protein folding; glycoprotein metabolic process; cell redox homeostasis; response to unfolded protein