Rabbit anti-Human, mouse ERO1B Polyclonal Antibody | anti-ERO1B antibody

ERO1B Antibody; HRP conjugated

Cat. Num. AAA7002938

• Gene Names: ERO1B; ERO1LB; Ero1beta
• Reactivity: Human, mouse
• Applications: ELISA
• Purity: >95%,Protein G purified
• Synonyms: ERO1B; Polyclonal Antibody; ERO1B Antibody; HRP conjugated; ERO1-like protein beta; ERO1-L-beta; Endoplasmic reticulum oxidoreductase beta; anti-ERO1B antibody

• Host: Rabbit
• Reactivity: Human, mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%,Protein G purified
• Form/Format: Liquid
• Sequence Length: 467

• Applicable Applications for anti-ERO1B antibody: ELISA (EIA)
• Immunogen: Recombinant human ERO1-like protein beta protein
• Conjugation: HRP
• Storage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Preparation and Storage: Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.

Related Product Information for anti-ERO1B antibody

Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis.

NCBI and Uniprot Product Information

• NCBI GI #: 239582761
• NCBI GeneID: 56605
• NCBI Accession #: NP_063944.3
• NCBI GenBank Nucleotide #: NM_019891.3
• UniProt Accession #: Q86YB8; Q5T1H4; Q8IZ11; Q9NR62; B4DF57
• Molecular Weight: 16,096 Da
• NCBI Official Full Name: ERO1-like protein beta
• NCBI Official Synonym Full Names: endoplasmic reticulum oxidoreductase beta
• NCBI Official Symbol: ERO1B
• NCBI Official Synonym Symbols: ERO1LB; Ero1beta
• NCBI Protein Information: ERO1-like protein beta
• UniProt Protein Name: ERO1-like protein beta
• Protein Family: ERO1-like protein
• UniProt Gene Name: ERO1B
• UniProt Synonym Gene Names: ERO1-L-beta
• UniProt Entry Name: ERO1B_HUMAN

Uniprot Description

ERO1LB: Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. Required for the folding of cell, thereby being a source of oxidative stress. Belongs to the EROs family.

Protein type: EC 1.8.4.-; Endoplasmic reticulum; Oxidoreductase

Chromosomal Location of Human Ortholog: 1q42.2-q43

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane

Molecular Function: oxidoreductase activity; oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor; protein binding; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; unfolded protein binding

Biological Process: 4-hydroxyproline metabolic process; cell redox homeostasis; extracellular matrix organization and biogenesis; glucose homeostasis; insulin processing; protein folding; protein maturation via protein folding