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Western Blot (WB) (Mouse Ern2 Antibody (C-term) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the Ern2 antibody detected the Ern2 protein (arrow).)

Rabbit anti-Mouse Ern2 Polyclonal Antibody | anti-Ern2 antibody

Mouse Ern2 Antibody (C-term)

Gene Names
Ern2; Ern1; Ire1; Ire1b
Reactivity
Mouse
Applications
Western Blot, ELISA
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
Ern2; Polyclonal Antibody; Mouse Ern2 Antibody (C-term); Serine/threonine-protein kinase/endoribonuclease IRE2; Endoplasmic reticulum-to-nucleus signaling 2; Inositol-requiring protein 2; Ire1-beta; IRE1b; mIre1; Serine/threonine-protein kinase; Endoribonuclease; 3126-; Ern2 {ECO:0000312|MGI:MGI:1349436}; anti-Ern2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This Mouse Ern2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 883-911 amino acids from the C-terminal region of mouse Ern2.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
883-911
Sequence Length
911
Applicable Applications for anti-Ern2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB~~1:1000
Antigen Type
Synthetic Peptide
Antigen Source
MOUSE
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Mouse Ern2 Antibody (C-term) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the Ern2 antibody detected the Ern2 protein (arrow).)

Western Blot (WB) (Mouse Ern2 Antibody (C-term) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the Ern2 antibody detected the Ern2 protein (arrow).)
Related Product Information for anti-Ern2 antibody
Ern2 plays a role in expression of the DDIT3 transcription factor, required for the unfolded-protein response, growth arrest and apoptosis. Has no effect on 28S ribosomal RNA cleavage, unlike the corresponding human protein.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
101262
NCBI Official Full Name
serine/threonine-protein kinase/endoribonuclease IRE2
NCBI Official Synonym Full Names
endoplasmic reticulum (ER) to nucleus signalling 2
NCBI Official Symbol
Ern2
NCBI Official Synonym Symbols
Ern1; Ire1; Ire1b
NCBI Protein Information
serine/threonine-protein kinase/endoribonuclease IRE2
UniProt Protein Name
Serine/threonine-protein kinase/endoribonuclease IRE2
UniProt Gene Name
Ern2
UniProt Synonym Gene Names
IRE1b; mIre1
UniProt Entry Name
ERN2_MOUSE

Uniprot Description

IRE2: Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Membrane protein, integral; Protein kinase, Other; Kinase, protein; Ribonuclease; Apoptosis; Other group; IRE family

Cellular Component: membrane; endoplasmic reticulum; integral to membrane; intracellular

Molecular Function: hydrolase activity; metal ion binding; magnesium ion binding; nucleotide binding; ribonuclease activity; protein kinase activity; transferase activity; protein serine/threonine kinase activity; endonuclease activity; transferase activity, transferring phosphorus-containing groups; bidentate ribonuclease III activity; kinase activity; catalytic activity; ATP binding

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; apoptosis; metabolic process; rRNA catabolic process; apoptotic chromosome condensation; mRNA processing; negative regulation of transcription, DNA-dependent; cell cycle arrest; phosphorylation; protein amino acid phosphorylation; response to unfolded protein

Research Articles on Ern2

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Product Notes

The Ern2 ern2 (Catalog #AAA9213633) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 883-911. The Mouse Ern2 Antibody (C-term) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Ern2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the Ern2 ern2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Ern2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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