Immunohistochemistry (IHC)
(Immunochemical staining of human ETV5 in human spleen with rabbit polyclonal antibody (1:10000, formalin-fixed paraffin embedded sections).)
Rabbit anti-Human ERM/ETV5 Polyclonal Antibody | anti-ETV5 antibody
Anti-ERM/ETV5 Antibody, Rabbit Polyclonal
Gene Names
ETV5; ERM
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
ERM/ETV5; Polyclonal Antibody; Anti-ERM/ETV5 Antibody; Rabbit Polyclonal; ETV5 Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-ERM Antibody; anti-ETV5 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human ETV5
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-ETV5 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:2500-1:10,000
Immunogen
A synthetic peptide corresponding to the center region of the Human ETV5
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human ETV5, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human ETV5 in human spleen with rabbit polyclonal antibody (1:10000, formalin-fixed paraffin embedded sections).)
Immunohistochemistry (IHC)
(Immunochemical staining of human ETV5 in human spleen with rabbit polyclonal antibody (1:10000, formalin-fixed paraffin embedded sections).)
Immunohistochemistry (IHC)
(Immunochemical staining of human ETV5 in human testis with rabbit polyclonal antibody (1:10000, formalin-fixed paraffin embedded sections).)
Immunohistochemistry (IHC)
(Immunochemical staining of human ETV5 in human testis with rabbit polyclonal antibody (1:10000, formalin-fixed paraffin embedded sections).)
Related Product Information for anti-ETV5 antibody
The ETS family of transcription factors is involved in several normal remodeling events and pathological processes including tumor progression. ETS transcription factors are divided into subfamilies based on the sequence and location of the ETS domain. ETV5 (Ets variant gene 5; also known as ERM) is a member of the PEA3 subfamily. Like other ETS proteins, Etv5 recognizes and binds GGAA/T, the Ets specific consensus sequence, through the Ets domain. Etv5 is involved in cell development. Etv5 expression is increased by IL-12/STAT4 signaling, not by IFNgamma-STAT1 signaling during Th1 cell development. Etv5 increases IL-10 production in vitro and in vivo by binding the Il10 locus and recruiting IL-10 inducing transcription factors.
References
Puli OR, et al. (2018) The transcription factor etv5 mediates brafv600e-induced proliferation and twist1 expression in papillary thyroid cancer cells. Neoplasia 20 (11): 1121-1134.Koh B, et al. (2017) Etv5 regulates il-10 production in th cells. J Immunol 198 (5): 2165-2171.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
510
NCBI Official Full Name
ETS translocation variant 5
NCBI Official Synonym Full Names
ets variant 5
NCBI Official Symbol
ETV5
NCBI Official Synonym Symbols
ERM
NCBI Protein Information
ETS translocation variant 5; ets-related molecule; ets-related protein ERM
UniProt Protein Name
ETS translocation variant 5
Protein Family
UniProt Gene Name
ETV5
UniProt Synonym Gene Names
ERM
UniProt Entry Name
ETV5_HUMAN
Uniprot Description
ERM: Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Belongs to the ETS family.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 3q28
Cellular Component: nucleus
Molecular Function: DNA binding; transcription factor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; regulation of synapse organization and biogenesis; neuromuscular synaptic transmission; locomotory behavior; positive regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation; cell differentiation; male germ-line stem cell division
Research Articles on ETV5
Similar Products
Product Notes
The ETV5 etv5 (Catalog #AAA8101020) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-ERM/ETV5 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ERM/ETV5 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:2500-1:10,000. Researchers should empirically determine the suitability of the ETV5 etv5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ERM/ETV5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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