Rabbit anti-Human ERLIN2 Polyclonal Antibody | anti-ERLIN2 antibody

ERLIN2, CT (ERLIN2, C8orf2, SPFH2, Erlin-2, Endoplasmic reticulum lipid raft-associated protein 2, Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (MaxLight 490)

Cat. Num. AAA6296564

• Gene Names: ERLIN2; NET32; SPFH2; SPG18; C8orf2; Erlin-2
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: ERLIN2; Polyclonal Antibody; CT (ERLIN2; C8orf2; SPFH2; Erlin-2; Endoplasmic reticulum lipid raft-associated protein 2; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (MaxLight 490); Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2; anti-ERLIN2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human ERLIN2.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.

• Applicable Applications for anti-ERLIN2 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:1000; Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 307-333 in the C-terminal region of human ERLIN2, UniProt Accession #O94905.
• Conjugate: MaxLight490
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Categories/Family for anti-ERLIN2 antibody

Antibodies; Lipoproteins

References

Wang, Y., et al. Biochim. Biophys. Acta 1793(11):1710-1718(2009). Pearce, M.M., et al. J. Biol. Chem. 284(16):10433-10445(2009). Pearce, M.M., et al. J. Biol. Chem. 282(28):20104-20115(2007). Browman, D.T., et al. J. Cell. Sci. 119 (PT 15), 3149-3160 (2006): Garcia, M.J., et al. Oncogene 24(33):5235-5245(2005).

NCBI and Uniprot Product Information

• NCBI GI #: 51242968
• NCBI GeneID: 11160
• NCBI Accession #: NP_001003790.1
• NCBI GenBank Nucleotide #: NM_001003790.3
• UniProt Accession #: O94905; Q6NW21; Q86VS6; Q86W49; A0JLQ1; A8K5S9; B4DM38; D3DSW0
• Molecular Weight: 22,939 Da
• NCBI Official Full Name: erlin-2 isoform 2
• NCBI Official Synonym Full Names: ER lipid raft associated 2
• NCBI Official Symbol: ERLIN2
• NCBI Official Synonym Symbols: NET32; SPFH2; SPG18; C8orf2; Erlin-2
• NCBI Protein Information: erlin-2; SPFH domain family, member 2; endoplasmic reticulum lipid raft-associated protein 2; stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2
• UniProt Protein Name: Erlin-2
• Protein Family: Erlin
• UniProt Gene Name: ERLIN2
• UniProt Synonym Gene Names: C8orf2; SPFH2; SPFH domain-containing protein 2
• UniProt Entry Name: ERLN2_HUMAN

NCBI Description

This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

Uniprot Description

SPFH2: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway. Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination. Forms a heteromeric complex with ERLIN1. Ubiquitous. Belongs to the band 7/mec-2 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Membrane protein, integral

Chromosomal Location of Human Ortholog: 8p11.2

Cellular Component: endoplasmic reticulum membrane; protein complex; endoplasmic reticulum; cytoplasm; integral to membrane; plasma membrane

Molecular Function: protein binding

Biological Process: ER-associated protein catabolic process

Disease: Spastic Paraplegia 18, Autosomal Recessive