Rabbit anti-Human ERI2 Polyclonal Antibody | anti-ERI2 antibody

ERI2, ID (ERI2, EXOD1, KIAA1504, ERI1 exoribonuclease 2, Exonuclease domain-containing protein 1) (Biotin)

Cat. Num. AAA6296527

• Gene Names: ERI2; EXOD1; ZGRF5
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: ERI2; Polyclonal Antibody; ID (ERI2; EXOD1; KIAA1504; ERI1 exoribonuclease 2; Exonuclease domain-containing protein 1) (Biotin); Exonuclease domain-containing protein 1; anti-ERI2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-ERI2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: ERI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 443-472 amino acids from the Central region of human ERI2.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(ERI2 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the ERI2 antibody detected the ERI2 protein (arrow).)

Related Product Information for anti-ERI2 antibody

EXOD1 (Exonuclease domain-containing protein 1), also known as ERI2 (ERI1 exoribonuclease 2), is a 691 amino acid protein that contains one exonuclease domain, which catalyzes the hydrolysis of unpaired or mismatched nucleotides. EXOD1 acitivity is dependent on the binding of two magnesium ions per subunit. There are four isoforms of EXOD1 that are produced as a result of alternative splicing events. The gene encoding EXOD1 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.

Product Categories/Family for anti-ERI2 antibody

Antibodies; KIAA; orf

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Kupsco, J.M., et al. RNA 12(12):2103-2117(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 218505674
• NCBI GeneID: 112479
• NCBI Accession #: NP_542394.2
• NCBI GenBank Nucleotide #: NM_080663.2
• UniProt Accession #: A8K979; Q6ZSJ2; Q96FR9; Q9P224; Q9Y6V3
• Molecular Weight: 66,834 Da
• NCBI Official Full Name: ERI1 exoribonuclease 2 isoform 2
• NCBI Official Synonym Full Names: ERI1 exoribonuclease family member 2
• NCBI Official Symbol: ERI2
• NCBI Official Synonym Symbols: EXOD1; ZGRF5
• NCBI Protein Information: ERI1 exoribonuclease 2
• UniProt Protein Name: ERI1 exoribonuclease 2
• Protein Family: ERI1 exoribonuclease
• UniProt Gene Name: ERI2
• UniProt Synonym Gene Names: EXOD1; KIAA1504