Rabbit anti-Human EPCR Polyclonal Antibody | anti-EPCR antibody

EPCR Rabbit Polyclonal

Cat. Num. AAA769032

• Gene Names: PROCR; CCCA; EPCR; CCD41
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: EPCR; Polyclonal Antibody; EPCR Rabbit Polyclonal; anti-EPCR antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 238

• Applicable Applications for anti-EPCR antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Protein C receptor, endothelial (EPCR)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using MBS769032 (PROCR Antibody) at dilution of 1:100)

Western Blot (WB)

(human spleen tissue were subjected to SDS PAGE followed by western blot with MBS769032 (PROCR antibody) at dilution of 1:400)

NCBI and Uniprot Product Information

• NCBI GI #: 34335272
• NCBI GeneID: 10544
• NCBI Accession #: NP_006395.2
• NCBI GenBank Nucleotide #: NM_006404.4
• Molecular Weight: 26,671 Da
• NCBI Official Full Name: endothelial protein C receptor
• NCBI Official Synonym Full Names: protein C receptor
• NCBI Official Symbol: PROCR
• NCBI Official Synonym Symbols: CCCA; EPCR; CCD41
• NCBI Protein Information: endothelial protein C receptor
• UniProt Protein Name: Endothelial protein C receptor
• UniProt Gene Name: PROCR
• UniProt Synonym Gene Names: EPCR; APC receptor
• UniProt Entry Name: EPCR_HUMAN

NCBI Description

The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013]

Uniprot Description

EPCR: a single-pass type I membrane protein. Binds activated protein C (APC), a serine protease that regulates thrombin (IIa) production. Plays a pivotal role in preventing blood coagulation through binding of activated protein C. Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney. The binding of APC to EPCR and PAR-1 increases invasion and chemotaxis.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 20q11.2

Cellular Component: cell surface; centrosome; extracellular region; focal adhesion; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; receptor activity

Biological Process: blood coagulation; immune response; leukocyte migration; negative regulation of coagulation