Western Blot (WB)
(BCL11B Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the BCL11B antibody detected the BCL11B protein (arrow).)
Rabbit BCL11B Polyclonal Antibody | anti-BCL11B antibody
BCL11B Antibody (Center)
Western Blot (WB)
(BCL11B Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the BCL11B antibody detected the BCL11B protein (arrow).)
Western Blot (WB)
(BCL11B Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the BCL11B antibody detected the BCL11B protein (arrow).)
closely related to BCL11A, a gene whose translocation may be
associated with B-cell malignancies. The specific function of this
gene has not yet been determined. Two alternatively spliced
transcript variants, which encode distinct isoforms, have been
reported.
Cherrier, T., et al. Oncogene 28(38):3380-3389(2009)
Ganguli-Indra, G., et al. PLoS ONE 4 (4), E5367 (2009) :
Cismasiu, V.B., et al. Virology 380(2):173-181(2008)
Desplats, P.A., et al. Neurobiol. Dis. 31(3):298-308(2008)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
Uniprot Description
Bcl-11B: Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 14q32.2
Cellular Component: nucleus
Molecular Function: protein binding; metal ion binding
Biological Process: positive T cell selection; post-embryonic camera-type eye development; regulation of lipid metabolic process; transcription, DNA-dependent; thymus development; regulation of neuron differentiation; T cell differentiation in the thymus; alpha-beta T cell differentiation; odontogenesis of dentine-containing teeth; negative regulation of cell proliferation; striatal medium spiny neuron differentiation; commitment of a neuronal cell to a specific type of neuron in the forebrain; T cell receptor V(D)J recombination; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptosis
Research Articles on BCL11B
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Product Notes
The BCL11B bcl11b (Catalog #AAA9211866) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 307-334. The BCL11B Antibody (Center) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's BCL11B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the BCL11B bcl11b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BCL11B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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