Rabbit ENO3 Polyclonal Antibody | anti-ENO3 antibody

ENO3 Rabbit Polyclonal

Cat. Num. AAA768999

• Gene Names: ENO3; MSE; GSD13
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: ENO3; Polyclonal Antibody; ENO3 Rabbit Polyclonal; anti-ENO3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 3

• Applicable Applications for anti-ENO3 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Enolase 3 (beta, muscle)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human skeletal muscle using MBS768999 (ENO3 antibody) at dilution of 1:50)

Western Blot (WB)

(human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with MBS768999 (ENO3 antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 4378983
• NCBI GeneID: 2027
• UniProt Accession #: P13929; Q96AE2; B4DUI6; B4DUM6; D3DTL2; E7ENK8
• Molecular Weight: 42,248 Da
• NCBI Official Full Name: enolase, partial
• NCBI Official Synonym Full Names: enolase 3
• NCBI Official Symbol: ENO3
• NCBI Official Synonym Symbols: MSE; GSD13
• NCBI Protein Information: beta-enolase
• UniProt Protein Name: Beta-enolase
• Protein Family: Enolase
• UniProt Gene Name: ENO3
• UniProt Synonym Gene Names: MSE
• UniProt Entry Name: ENOB_HUMAN

NCBI Description

This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme is found in skeletal muscle cells in the adult where it may play a role in muscle development and regeneration. A switch from alpha enolase to beta enolase occurs in muscle tissue during development in rodents. Mutations in this gene have be associated glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jul 2010]

Uniprot Description

ENO3: Appears to have a function in striated muscle development and regeneration. Defects in ENO3 are the cause of glycogen storage disease type 13 (GSD13). A metabolic disorder that results in exercise-induced myalgias, generalized muscle weakness and fatigability. It is characterized by increased serum creatine kinase and decreased enolase 3 activity. Dramatically reduced protein levels with focal sarcoplasmic accumulation of glycogen- beta particles are detected on ultrastructural analysis. Belongs to the enolase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Lyase; EC 4.2.1.11

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: cytoplasm; cytosol; extracellular space; phosphopyruvate hydratase complex; plasma membrane

Molecular Function: magnesium ion binding; phosphopyruvate hydratase activity; protein heterodimerization activity; protein homodimerization activity

Biological Process: aging; gluconeogenesis; response to drug; skeletal muscle regeneration

Disease: Glycogen Storage Disease Xiii