Western Blot (WB)
(Western Blot: Sample: Recombinant EDN1, Mouse.)
Rabbit anti-Mouse Endothelin 1 (EDN1) Polyclonal Antibody | anti-EDN1 antibody
Polyclonal Antibody to Endothelin 1 (EDN1)
MGHHHHHHSG SEF- ENGVQSPP PSTPWRPRRS KRCSCSSLMD KECVYFCHLD IIWVNTPERV VPYGLGGSSR SKRSLKDLLP NKATDQAVRC QCAHQKDKKC WNFCQAGKEL RAQSTMQKSL KDSKKGKPCS KLGKKCIYQQ LVEGRKLRRL EAISNSIKAS FRVAKLKAEL
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Recombinant EDN1, Mouse.)
Western Blot (WB)
(Western Blot: Sample: Recombinant EDN1, Mouse.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Lung Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Lung Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Pancreas Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Pancreas Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Liver Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Liver Tissue.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the endothelin family of peptides. The encoded preproprotein undergoes proteolytic processing to generate a peptide before secretion by the vascular endothelial cells. The mature peptide has various biological activities such as vasoconstriction, cell proliferation, stimulation of hormone release and modulation of central nervous activity. Mice lacking the encoded protein exhibit neonatal lethality accompanied with numerous craniofacial and cardiovascular defects due to disruption in cranial and cardiac neural crest cell patterning during early embryogenesis. [provided by RefSeq, Feb 2016]
Uniprot Description
EDN1: Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 13 A4|13 20.82 cM
Cellular Component: cytoplasm; extracellular region; extracellular space
Molecular Function: cytokine activity; endothelin A receptor binding; endothelin B receptor binding; hormone activity; protein binding; receptor binding
Biological Process: artery smooth muscle contraction; blood vessel morphogenesis; body fluid secretion; branching involved in blood vessel morphogenesis; calcium-mediated signaling; cartilage development; cell growth; cell surface receptor signaling pathway; cell-cell signaling; dorsal/ventral pattern formation; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); epithelial fluid transport; G-protein coupled receptor signaling pathway; G-protein signaling, phospholipase D activating pathway; glucose transport; heart development; histamine secretion; in utero embryonic development; inositol phosphate-mediated signaling; membrane depolarization; middle ear morphogenesis; negative regulation of cAMP biosynthetic process; negative regulation of cellular protein metabolic process; negative regulation of hormone secretion; negative regulation of nitric-oxide synthase biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; neural crest cell development; nitric oxide transport; peptide hormone secretion; phosphoinositide 3-kinase cascade; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell size; positive regulation of heart rate; positive regulation of hormone secretion; positive regulation of JUN kinase activity; positive regulation of MAP kinase activity; positive regulation of mitotic nuclear division; positive regulation of odontogenesis; positive regulation of prostaglandin secretion; positive regulation of smooth muscle cell proliferation; positive regulation of smooth muscle contraction; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; prostaglandin biosynthetic process; protein kinase C deactivation; protein kinase C-activating G-protein coupled receptor signaling pathway; regulation of blood pressure; regulation of blood vessel size; regulation of pH; regulation of sensory perception of pain; regulation of systemic arterial blood pressure by endothelin; regulation of vasoconstriction; respiratory gaseous exchange; response to hypoxia; rhythmic excitation; sensory perception of pain; skeletal system development; superoxide anion generation; vasoconstriction; vein smooth muscle contraction
Research Articles on EDN1
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Product Notes
The EDN1 edn1 (Catalog #AAA2013568) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Endothelin 1 (EDN1) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Endothelin 1 (EDN1) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the EDN1 edn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSG SEF- ENGVQSPP PSTPWRPRRS KRCSCSSLMD KECVYFCHLD IIWVNTPERV VPYGLGGSSR SKRSLKDLLP NKATDQAVRC QCAHQKDKKC WNFCQAGKEL RAQSTMQKSL KDSKKGKPCS KLGKKCIYQQ LVEGRKLRRL EAISNSIKAS FRVAKLKAEL. It is sometimes possible for the material contained within the vial of "Endothelin 1 (EDN1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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