Western Blot (WB)
(EMX2 Antibody (Center) western blot analysis in HL-60 cell line lysates (15ug/lane).This demonstrates the EMX2 antibody detected the EMX2 protein (arrow).)
Rabbit EMX2 Polyclonal Antibody | anti-EMX2 antibody
EMX2 Antibody (Center)
Western Blot (WB)
(EMX2 Antibody (Center) western blot analysis in HL-60 cell line lysates (15ug/lane).This demonstrates the EMX2 antibody detected the EMX2 protein (arrow).)
Western Blot (WB)
(EMX2 Antibody (Center) western blot analysis in HL-60 cell line lysates (15ug/lane).This demonstrates the EMX2 antibody detected the EMX2 protein (arrow).)
Flow Cytometry (FC/FACS)
(EMX2 Antibody (Center) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(EMX2 Antibody (Center) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
factor that is the homolog to the 'empty spiracles' gene in
Drosophila. Research on this gene in humans has focused on its
expression in three tissues: dorsal telencephalon, olfactory
neuroepithelium, and urogenetial system. It is expressed in the
dorsal telencephalon during development in a low rostral-lateral to
high caudal-medial gradient and is proposed to pattern the
neocortex into defined functional areas. It is also expressed in
embryonic and adult olfactory neuroepithelia where it complexes
with eukaryotic translation initiation factor 4E (eIF4E) and
possibly regulates mRNA transport or translation. In the developing
urogenital system, it is expressed in epithelial tissues and is
negatively regulated by HOXA10. Alternative splicing results in
multiple transcript variants encoding distinct proteins.
Bayatti, N., et al. Eur. J. Neurosci. 28(8):1449-1456(2008)
Merello, E., et al. Am. J. Med. Genet. A 146A (9), 1142-1150 (2008) :
Treloar, S.A., et al. Mol. Hum. Reprod. 13(8):587-594(2007)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. It is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10. Alternative splicing results in multiple transcript variants encoding distinct proteins.[provided by RefSeq, Sep 2009]
Uniprot Description
EMX2: Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system. Defects in EMX2 are the cause of schizencephaly (SCHZC). Schizencephaly is an extremely rare human congenital disorder characterized by a full-thickness cleft within the cerebral hemispheres. These clefts are lined with gray matter and most commonly involve the parasylvian regions. Large portions of the cerebral hemispheres may be absent and replaced by cerebro- spinal fluid. Belongs to the EMX homeobox family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 10q26.1
Cellular Component: nucleus
Molecular Function: protein binding; sequence-specific DNA binding
Biological Process: anterior/posterior pattern formation; response to drug; forebrain cell migration; neuron differentiation; dentate gyrus development; regulation of transcription, DNA-dependent; cell proliferation in forebrain; cerebral cortex regionalization
Disease: Schizencephaly
Research Articles on EMX2
Similar Products
Product Notes
The EMX2 emx2 (Catalog #AAA9204252) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 111-138. The EMX2 Antibody (Center) reacts with Human (Predicted Reactivity: Bovine, Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's EMX2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS). WB~~1:1000. Researchers should empirically determine the suitability of the EMX2 emx2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "EMX2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
