Rabbit anti-Human EMP2 Polyclonal Antibody | anti-EMP2 antibody

EMP2 Antibody

Cat. Num. AAA9410434

• Gene Names: EMP2; XMP
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: EMP2; Polyclonal Antibody; EMP2 Antibody; XMP; anti-EMP2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total EMP2 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 1.5 mg/ml (varies by lot)
• Sequence Length: 167

• Applicable Applications for anti-EMP2 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:25-1:100
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human epithelial membrane protein 2
• Target Name: EMP2
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/20.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/20.)

Related Product Information for anti-EMP2 antibody

EMP-2 (epithelial membrane protein 2), also known as XMP, is a 167 amino acid multi-pass membrane protein that contains four-transmembrane domains and belongs to the GAS3/PMP22 (growth arrest-specific-3/peripheral myelin protein-22) family. Localized to lipid raft domains in the plasma membrane, EMP-2 regulates the expression of several target proteins and is necessary for blastocyst implantation in the uterine endometrium. Specifically, EMP-2 mediates blastocyst implantation by controlling the cell membrane expression of MHC and glycosylphosphatidylinositol-anchored proteins, as well as Integrins and caveolin-1. In adult tissues, EMP-2 is expressed in heart, lung, ovary and intestine, while fetal expression is highest in kidney, brain and liver. Overexpression of EMP-2 is associated with endometrial adenocarcinoma, suggesting a possible role for EMP-2 in tumorigenesis.

Product Categories/Family for anti-EMP2 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 4503561
• NCBI GeneID: 2013
• NCBI Accession #: NP_001415.1
• NCBI GenBank Nucleotide #: NM_001424.5
• UniProt Accession #: P54851; B2R7V6; D3DUF8
• Molecular Weight: 19,199 Da
• NCBI Official Full Name: epithelial membrane protein 2
• NCBI Official Synonym Full Names: epithelial membrane protein 2
• NCBI Official Symbol: EMP2
• NCBI Official Synonym Symbols: XMP
• NCBI Protein Information: epithelial membrane protein 2
• UniProt Protein Name: Epithelial membrane protein 2
• Protein Family: Epithelial membrane protein
• UniProt Gene Name: EMP2
• UniProt Synonym Gene Names: XMP; EMP-2
• UniProt Entry Name: EMP2_HUMAN

NCBI Description

This gene encodes a tetraspan protein of the PMP22/EMP family. The encoded protein regulates cell membrane composition. It has been associated with various functions including endocytosis, cell signaling, cell proliferation, cell migration, cell adhesion, cell death, cholesterol homeostasis, urinary albumin excretion, and embryo implantation. It is known to negatively regulate caveolin-1, a scaffolding protein which is the main component of the caveolae plasma membrane invaginations found in most cell types. Through activation of PTK2 it positively regulates vascular endothelial growth factor A. It also modulates the function of specific integrin isomers in the plasma membrane. Up-regulation of this gene has been linked to cancer progression in multiple different tissues. Mutations in this gene have been associated with nephrotic syndrome type 10 (NPHS10). [provided by RefSeq, Mar 2015]

Uniprot Description

EMP2: Belongs to the PMP-22/EMP/MP20 family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p13.2

Cellular Component: Golgi membrane; Golgi apparatus; cell surface; apical part of cell; cytoplasm; apical plasma membrane; plasma membrane; integral to membrane; caveola; cytoplasmic vesicle; nucleus; lipid raft

Molecular Function: integrin binding; protein binding; protein kinase binding; kinase binding

Biological Process: cell death; regulation of kinase activity; cell migration; blood vessel endothelial cell migration; cell-matrix adhesion; actin filament organization; bleb formation; lipid raft formation; regulation of angiogenesis; cell proliferation; regulation of glomerular filtration; early endosome to late endosome transport; positive regulation of cell proliferation; activation of protein kinase activity; positive regulation of cell-matrix adhesion; cell adhesion; embryo implantation; T cell mediated cytotoxicity

Disease: Nephrotic Syndrome, Type 10