Rabbit anti-Human, Mouse ELL Polyclonal Antibody | anti-ELL antibody

ELL Rabbit Polyclonal

Cat. Num. AAA768972

• Gene Names: ELL; MEN; ELL1; PPP1R68; C19orf17
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: ELL; Polyclonal Antibody; ELL Rabbit Polyclonal; anti-ELL antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 621

• Applicable Applications for anti-ELL antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Elongation factor RNA polymerase II
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human ovary tumor using MBS768972 (ELL antibody) at dilution of 1:50)

Western Blot (WB)

(HeLa cells were subjected to SDS PAGE followed by western blot with MBS768972 (ELL antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 601793
• NCBI GeneID: 8178
• Molecular Weight: 68,265 Da
• NCBI Official Full Name: ELL
• NCBI Official Synonym Full Names: elongation factor for RNA polymerase II
• NCBI Official Symbol: ELL
• NCBI Official Synonym Symbols: MEN; ELL1; PPP1R68; C19orf17
• NCBI Protein Information: RNA polymerase II elongation factor ELL
• UniProt Protein Name: RNA polymerase II elongation factor ELL
• Protein Family: ELL-associated factor
• UniProt Gene Name: ELL
• UniProt Synonym Gene Names: C19orf17
• UniProt Entry Name: ELL_HUMAN

Uniprot Description

ELL: Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein. Belongs to the ELL/occludin family.

Protein type: Nuclear receptor co-regulator; Oncoprotein; Transcription initiation complex

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: actin cytoskeleton; Cajal body; cytoplasm; nuclear speck; nucleoplasm; nucleus; plasma membrane; transcription elongation factor complex

Molecular Function: phosphatase binding; protein binding

Biological Process: in utero embryonic development; positive regulation of RNA elongation; positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase III promoter; RNA elongation from RNA polymerase II promoter; snRNA transcription from RNA polymerase II promoter; snRNA transcription from RNA polymerase III promoter; transcription from RNA polymerase II promoter