Rabbit EFNA1 Polyclonal Antibody | anti-EFNA1 antibody

EFNA1 Polyclonal Antibody

Cat. Num. AAA2526064

• Gene Names: EFNA1; B61; EFL1; ECKLG; EPLG1; LERK1; LERK-1; TNFAIP4
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: EFNA1; Polyclonal Antibody; EFNA1 Polyclonal Antibody; B61; EFL1; ECKLG; EPLG1; LERK1; LERK-1; TNFAIP4; anti-EFNA1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1.5mg/mL (varies by lot)
• Sequence Length: 205

• Applicable Applications for anti-EFNA1 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:150
• Immunogen: Recombinant protein of human EFNA1
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using EFNA1 Polyclonal Antibody at dilution 1:37)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using EFNA1 Polyclonal Antibody at dilution 1:37)

Related Product Information for anti-EFNA1 antibody

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis.

NCBI and Uniprot Product Information

• NCBI GI #: 33359682
• NCBI GeneID: 1942
• NCBI Accession #: NP_004419.2
• NCBI GenBank Nucleotide #: NM_004428.2
• Molecular Weight: 21,246 Da
• NCBI Official Full Name: ephrin-A1 isoform a
• NCBI Official Synonym Full Names: ephrin-A1
• NCBI Official Symbol: EFNA1
• NCBI Official Synonym Symbols: B61; EFL1; ECKLG; EPLG1; LERK1; LERK-1; TNFAIP4
• NCBI Protein Information: ephrin-A1; TNF alpha-induced protein 4; eph-related receptor tyrosine kinase ligand 1; immediate early response protein B61; ligand of eph-related kinase 1; tumor necrosis factor alpha-induced protein 4; tumor necrosis factor, alpha-induced protein 4
• UniProt Protein Name: Ephrin-A1
• Protein Family: Ephrin
• UniProt Gene Name: EFNA1
• UniProt Synonym Gene Names: EPLG1; LERK1; TNFAIP4; LERK-1; TNF alpha-induced protein 4
• UniProt Entry Name: EFNA1_HUMAN

NCBI Description

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]

Uniprot Description

EFNA1: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. Belongs to the ephrin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor; Cell development/differentiation; Ligand, receptor tyrosine kinase; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 1q21-q22

Cellular Component: anchored to plasma membrane; integral to plasma membrane; plasma membrane; extracellular region

Molecular Function: protein binding; ephrin receptor binding; receptor binding

Biological Process: axon guidance; cell migration; activation of MAPK activity; notochord formation; negative regulation of transcription from RNA polymerase II promoter; regulation of axonogenesis; regulation of blood vessel endothelial cell migration; regulation of angiogenesis; regulation of cell adhesion mediated by integrin; positive regulation of peptidyl-tyrosine phosphorylation; cell-cell signaling; ephrin receptor signaling pathway; angiogenesis; regulation of peptidyl-tyrosine phosphorylation