Rabbit EFHD2 Polyclonal Antibody | anti-EFHD2 antibody

EFHD2 Antibody

Cat. Num. AAA150334

• Gene Names: EFHD2; SWS1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: EFHD2 Antibody is affinity chromatography purified via peptide column.
• Synonyms: EFHD2; Polyclonal Antibody; EFHD2 Antibody; SWS1; EF-hand domain-containing protein D2; Swiprosin-1; EF-hand domain family; member D2; anti-EFHD2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: EFHD2 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 240

• Applicable Applications for anti-EFHD2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: EFHD2 antibody can be used for detection of EFHD2 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: EFHD2 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human EFHD2.
• Buffer: EFHD2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: EFHD2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of EFHD2 in mouse brain tissue lysate with EFHD2 antibody at (A) 1 and (B) 2 μg/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of EFHD2 in human brain tissue with EFHD2 antibody at 5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of EFHD2 in human brain tissue with EFHD2 antibody at 20 μg/mL.)

Related Product Information for anti-EFHD2 antibody

EFHD2 Antibody: EFHD2, also known as Swiprosin-1 or SWS1, is an EF-hand and coiled-coil-containing adaptor protein that plays a role in lymphocyte physiology. EFHD2 exhibits the highest expression in CD8+ T cells and immature B cells. It provides a membrane scaffold that is required for the Syk-, SLP-65-, and PLCgamma2-dependent B-cell receptor (BCR)-induced calcium flux. EFHD2 may also regulate BCR-induced immature and primary B-cell apoptosis. It controls spontaneous apoptosis through the regulation of BCL2L1 abundance. Also, EFHD2 plays a role as negative regulator of the canonical NF-κB-activating branch.

NCBI and Uniprot Product Information

• NCBI GI #: 20149675
• NCBI GeneID: 79180
• NCBI Accession #: NP_077305
• NCBI GenBank Nucleotide #: NM_024329.5
• UniProt Accession #: Q96C19; Q5JYW9
• Molecular Weight: 26,697 Da
• NCBI Official Full Name: EF-hand domain-containing protein D2
• NCBI Official Synonym Full Names: EF-hand domain family, member D2
• NCBI Official Symbol: EFHD2
• NCBI Official Synonym Symbols: SWS1
• NCBI Protein Information: EF-hand domain-containing protein D2; swiprosin 1; swiprosin-1; EF hand domain containing 2; EF hand domain family, member D2
• UniProt Protein Name: EF-hand domain-containing protein D2
• Protein Family: EF-hand domain-containing protein
• UniProt Gene Name: EFHD2
• UniProt Synonym Gene Names: SWS1
• UniProt Entry Name: EFHD2_HUMAN

Uniprot Description

EFHD2: May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 1p36.21

Cellular Component: lipid raft

Molecular Function: calcium ion binding