Rabbit EDNRB / Endothelin B Receptor Polyclonal Antibody | anti-EDNRB antibody

Rabbit Polyclonal to Human EDNRB / Endothelin B Receptor

Cat. Num. AAA243624

• Gene Names: EDNRB; ETB; ET-B; ETBR; ETRB; HSCR; WS4A; ABCDS; ET-BR; HSCR2
• Reactivity: Gorilla, Human, Monkey; Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: EDNRB / Endothelin B Receptor; Polyclonal Antibody; Rabbit Polyclonal to Human EDNRB / Endothelin B Receptor; Anti-EDNRB / Endothelin B Receptor Antibody (N-Terminus) IHC-plus; EDNRB; ABCDS; Endothelin B receptor; Etb receptor; ET-B; Et-b receptor; Et-b-r; ET-RB; ETBR; ETRB; Etb-svr; WS4A; Endothelin receptor type B; ET-BR; ETB; HSCR; HSCR2; Human EDNRB; Endothelin B Receptor; anti-EDNRB antibody

• Host: Rabbit
• Reactivity: Gorilla, Human, Monkey; Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human EDNRB. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 442

• Applicable Applications for anti-EDNRB antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (4 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 17 amino acid peptide from N-terminal extracellular domain of human EDNRB. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%); Gibbon (94%); Dog (88%); Marmoset, Goat, Bovine (82%).
• Immunogen Type: Synthetic peptide
• Immunogen: EDNRB / Endothelin B Receptor antibody was raised against synthetic 17 amino acid peptide from N-terminal extracellular domain of human EDNRB. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%); Gibbon (94%); Dog (88%); Marmoset, Goat, Bovine (82%).
• Antigen Modification: N-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-EDNRB / Endothelin B Receptor antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-EDNRB antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-EDNRB / Endothelin B Receptor antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-EDNRB / Endothelin B Receptor antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-EDNRB antibody

The Endothelin Receptor ETB is expressed in most tissues. Mutations of the receptor gene are responsible for Hirschsprung disease type 2, a multigenic disorder with phenotypes such as bicolored irides, megacolon, hypopigmentation, and hearing loss. The ETB receptor has similar affinity for all three endothelins and activates a phosphatidylinositol-calcium second messenger system.

Product Categories/Family for anti-EDNRB antibody

Family: GPCR; Subfamily: Endothelin

NCBI and Uniprot Product Information

• NCBI GI #: 4557547
• NCBI GeneID: 1910
• NCBI Accession #: NP_000106.1
• NCBI GenBank Nucleotide #: NM_000115.3
• UniProt Accession #: P24530; O15343; Q59GB1; Q5W0G9; Q8NHM6; Q8NHM7; Q8NHM8; Q8NHM9; Q9UD23; Q9UQK3; A2A2Z8; A8K3T4; AAB24922
• Molecular Weight: 59,480 Da
• NCBI Official Full Name: endothelin B receptor isoform 1
• NCBI Official Synonym Full Names: endothelin receptor type B
• NCBI Official Symbol: EDNRB
• NCBI Official Synonym Symbols: ETB; ET-B; ETBR; ETRB; HSCR; WS4A; ABCDS; ET-BR; HSCR2
• NCBI Protein Information: endothelin B receptor; endothelin receptor non-selective type
• UniProt Protein Name: Endothelin B receptor
• Protein Family: Endothelin B receptor
• UniProt Gene Name: EDNRB
• UniProt Synonym Gene Names: ETRB; ET-B; ET-BR
• UniProt Entry Name: EDNRB_HUMAN

NCBI Description

The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Uniprot Description

ETB: a G protein-coupled receptor which activates a phosphatidylinoitol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutation in endothelin receptor type B gene. Essential component in the normal development of two neuronal crest-derived cell lineages. Two splice variant isoforms have been described.

Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 13q22

Cellular Component: nuclear membrane; integral to plasma membrane; plasma membrane; lipid raft

Molecular Function: endothelin receptor activity; protein binding; peptide hormone binding; type 1 angiotensin receptor binding

Biological Process: epithelial fluid transport; cGMP-mediated signaling; regulation of fever; negative regulation of cellular protein metabolic process; response to pain; negative regulation of transcription from RNA polymerase II promoter; sensory perception of pain; vein smooth muscle contraction; response to organic cyclic substance; vasodilation; enteric nervous system development; regulation of epithelial cell proliferation; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; regulation of blood pressure; positive regulation of cell proliferation; melanocyte differentiation; regulation of pH; neural crest cell migration; aging; nervous system development; vasoconstriction; posterior midgut development; negative regulation of adenylate cyclase activity; macrophage chemotaxis; peripheral nervous system development; negative regulation of neuron maturation; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of sensory perception of pain; positive regulation of protein amino acid phosphorylation; negative regulation of apoptosis

Disease: Abcd Syndrome; Waardenburg Syndrome, Type 4a; Hirschsprung Disease, Susceptibility To, 2